A Phase 4 interventional study of 5- fluorouracil and radiotherapy in Keloid Scar, sponsored by Queen Mary University of London. Withdrawn at 1 site in United Kingdom. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2023-09-18.
Sponsored by Queen Mary University of London · Phase 4, Interventional, and Treatment
To clarify the mechanisms of Keloid scar formation.
Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment
Identify the genetic link with Keloid scar formation.
Quantify the psychological/social impact in keloid scarring patients
138 studies on the registry are indexed under Keloid; 26 are open to participants now.
Browse Keloid studies →Queen Mary University of London is the lead sponsor of 253 studies on the registry; 58 are open to participants now.
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Exclusion Criteria:
Open wound at or proximity of the lesion
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with small keloidal scars to have intralesional 5FU injected
Drug: 5- fluorouracil
Large keloid scars undergo extralesional excision and radiotherapy
Radiation: radiotherapy
Drug: Triamcinolone
5mg of 5FU injected per 1cm square, at 6 week intervals for 30 weeks = 6 sessions
after complete excision of keloid they have a single session of radiotherapy
TAC 10mg in 1ml injected intralesional
Keloid Scar Reduction
Using a 3D scanner to observe the reduction of the scar volume measured in cubic centimetres
Time frame: 18 months
This study is withdrawn, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Fluorouracil · Triamcinolone
Queen Mary University of London →