An interventional study of Plasmalyte A and Normal Saline in Wounds and Injuries, Multiple Trauma and Disorder of Fluid Balance, sponsored by University of California, Davis. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-05-30.
Sponsored by University of California, Davis · Not applicable, Interventional, and Treatment
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
Electrolyte-containing intravenous fluids are routinely administered to patients in the first few hours after acute traumatic injury. Although Normal Saline (0.9% sodium chloride) is commonly used in this setting, it causes a hyperchloremic acidosis that may exacerbate metabolic derangements that occur after acute injury. Plasmalyte A is a solution that more closely matches physiologic electrolyte levels. In this study, we will evaluate whether Plasmalyte A results in less disturbance of the base deficit 24 hours following traumatic injury than does Normal Saline.
5,085 studies on the registry are indexed under Wounds and Injuries; 849 are open to participants now.
This study's enrollment of 46 is below the median of 52 across 3,261 interventional studies indexed under Wounds and Injuries.
Browse Wounds and Injuries studies →University of California, Davis is the lead sponsor of 809 studies on the registry; 145 are open to participants now.
Of its 67 completed or terminated interventional studies of FDA-regulated products, 43 (64%) have results posted.
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Meets at least one of the following criteria:
Exclusion Criteria:
Administration of Plasmalyte A as the standard intravenous fluid during the first 24 hours after arrival to the hospital
Other: Plasmalyte A
Administration of Normal Saline as the standard intravenous fluid during the first 24 hours after arrival to the hospital
Other: Normal Saline
Intravenous fluid
Intravenous fluid
Change in the base deficit
Base deficit at 24 hours after randomization minus the base deficit at randomization
Time frame: 24 hours after randomization
Mortality
Time frame: Hospital discharge
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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