An observational study in Colorectal Cancer, sponsored by University Hospital Dubrava. Completed at 1 site in Croatia. Open to participants aged 20 Years to 90 Years. Per ClinicalTrials.gov, last updated 2013-07-16.
Sponsored by University Hospital Dubrava · Observational
Based on our previous research, this study aims to determine reliable surgical stress response markers in patients undergoing radical resection of colorectal cancer.
Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation.
The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection.
In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer.
This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.
5,599 studies on the registry are indexed under Colorectal Neoplasms; 1,459 are open to participants now.
This study's enrollment of 28 is below the median of 250 across 1,226 observational studies indexed under Colorectal Neoplasms.
Browse Colorectal Neoplasms studies →University Hospital Dubrava is the lead sponsor of 39 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with colorectal cancer treated in the University Hospital Dubrava
Exclusion Criteria:
Patients with pathohistologically verified colorectal cancer or adenoma with epithelial dysplasia
Procedure: colorectal cancer resection
Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site
Also known as: Hemicolectomy, Rectosigmoid resection
Postoperative changes of serum cytokine levels
Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.
Time frame: 1 day, 2 days and 7 days postoperatively
Early postoperative complications
Time frame: Within one month after surgery
This study is completed, as verified in Jul 2013. You cannot join it, but the record below documents what was studied.
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University Hospital Dubrava