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CompletedNCT01237834Updated Oct 30, 2014

Physiological Responses in Tobacco Chippers

An observational study in Smoking and Stress, sponsored by Oregon Health and Science University. Completed at 1 site in United States. Open to participants aged 25 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-10-30.

Sponsored by Oregon Health and Science University · Observational

Study type
Observational
Time perspective
Cross-sectional
Enrollment
178
Ages
25 Years to 55 Years
Sex
All
01

Study summary

This study will analyze a series of biological and behavioral markers in different populations of smokers. The study groups will differ in their cigarette consumption and level of nicotine dependence. This analysis will help to identify factors that might be important for smoking behavior and nicotine addiction. The results from this study will contribute to improve campaigns for smoking prevention and treatments for smoking cessation.

02

Conditions studied

  • Smoking
  • Stress
03

In context

Lead sponsor

Oregon Health and Science University is the lead sponsor of 676 studies on the registry; 136 are open to participants now.

Of its 49 completed or terminated interventional studies of FDA-regulated products, 36 (73%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

General population

Inclusion criteria

  • healthy adults
  • age 25-55

Exclusion criteria

Exclusion Criteria:

  • alcohol or drug addiction
  • unstable significant medical problems
  • neurologic disease
  • medications known to affect CNS function or impact physiologic parameters measured in the study
  • significant visual impairment
  • breath carbon monoxide (BCO) level of less than 10 ppm for smokers
  • breath carbon monoxide (BCO) level of more than 5 ppm for non-smokers
  • for heavy regular smokers: erratic smoking history (i.e. they must have smoked an average of 15 cigarettes daily for at least one year)
05

Study design

Time perspective
Cross-sectional
Enrollment
178 participants (actual)

Groups and cohorts

  • Heavy smokers, 15 or more cigarettes/day

    Nicotine dependent.

  • Light smokers (chippers)

    Less than 2 cigarettes/day, at least 2 days/week. Non nicotine-dependent.

  • Non smokers
06

What researchers measure

Primary outcomes

  1. Electroencephalography

    Electroencephalography will be measured during performance on a hard cognitive task.

    Time frame: Changes from baseline during a hard cognitive task

Secondary outcomes

  1. Salivary cortisol

    Salivary cortisol will be measured at baseline, during a hard cognitive task and 30 minutes after the cognitive task.

    Time frame: Changes from baseline during performance on a hard cognitive task

07

Study locations

1 site
  • Oregon Health and Science University
    Portland, Oregon 97239, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 30, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01237834
Lead sponsor
Oregon Health and Science University
Responsible party
Barry S. Oken (MD, Oregon Health and Science University) — Principal investigator
First posted
Nov 10, 2010
Start date
Nov 2010
Primary completion
Jan 2013
Completion
Jan 2013
Last update
Oct 30, 2014

Study contacts

Barry Oken
principal investigator · Oregon Health and Science University
Laura Carim Todd
principal investigator · Oregon Health and Science University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.

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