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CompletedNCT01232842Updated Jul 11, 2016

Biomarker Study in Tissue Samples From Patients With Acute Myeloid Leukemia

An observational study in Leukemia, sponsored by Children's Oncology Group. Completed. Open to female participants aged Up to 120 Years. Per ClinicalTrials.gov, last updated 2016-07-11.

Sponsored by Children's Oncology Group · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
20
Ages
Up to 120 Years
Sex
Female
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Study summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This research study is studying biomarkers in tissue samples from patients with acute myeloid leukemia.

Read the detailed description

OBJECTIVES:

  • Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+ precursors or in which uncontrolled growth is restricted to CD33+ precursors.

OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation patterns by cytogenetic/molecular analysis and/or Humara assay.

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Conditions studied

  • Leukemia

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Keywords

  • adult acute myeloid leukemia
  • childhood acute myeloid leukemia/other myeloid malignancies
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In context

Leukemia

5,441 studies on the registry are indexed under Leukemia; 636 are open to participants now.

This study's planned enrollment of 20 is below the median of 120 across 744 observational studies indexed under Leukemia.

Browse Leukemia studies →

Lead sponsor

Children's Oncology Group is the lead sponsor of 436 studies on the registry; 34 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 11 (92%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 120 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Diagnosed with acute myeloid leukemia.

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Diagnosed with acute myeloid leukemia
  • Known CD34+ progenitor cells
  • Available freshly isolated, uncultured cell samples

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
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Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
20 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Interventions

  • Geneticcytogenetic analysis
  • OtherHUMARA assay
  • Otherfluorescence activated cell sorting
  • Otherlaboratory biomarker analysis
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What researchers measure

Primary outcomes

  1. Frequency of AML that originate in CD33+ or in which uncontrolled growth is restricted to CD33+ precursors

  2. Extent of clonal hematopoiesis in small numbers of AML cells

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 11, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01232842
Lead sponsor
Children's Oncology Group
Collaborators
National Cancer Institute (NCI)
Responsible party
Sponsor
First posted
Nov 2, 2010
Start date
Oct 2010
Primary completion
Jul 2016
Last update
Jul 11, 2016

Study contacts

Roland Walter, MD, PhD
principal investigator · Fred Hutchinson Cancer Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.

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