An observational study in Lipid Overnutrition and Constitutional Thinness, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Completed at 3 sites in France. Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-05-05.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Observational
For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.
This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.
66 studies on the registry are indexed under Thinness; 11 are open to participants now.
This study's planned enrollment of 26 is below the median of 275 across 22 observational studies indexed under Thinness.
Browse Thinness studies →Centre Hospitalier Universitaire de Saint Etienne is the lead sponsor of 597 studies on the registry; 127 are open to participants now.
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Constitutionnal thinness women and healthy volonteers(women)
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria (common to the two groups):
Women with a a body mass index of less than 16.5 kg/m2
Behavioral: Lipid overnutrition
Women with a body mass index between 20 and 25 kg/m2
Behavioral: Lipid overnutrition
During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).
gene expression
Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues
Time frame: After one month of lipid overnutrition
Anthropometric parameter
Lean mass
Time frame: After one month of lipid overnutrition
Autonomic nervous system activity
Heart rate variability analyses using ECG Holter monitoring
Time frame: After one month of lipid overnutrition
gastrointestinal hormone level
Serum level of GLP1
Time frame: After one month of lipid overnutrition
Anthropometric parameter
Weight
Time frame: After one month of lipid overnutrition
Anthropometric parameter
Fat mass
Time frame: After one month of lipid overnutrition
gastrointestinal hormone level
Serum level of ghréline
Time frame: After one month of lipid overnutrition
gastrointestinal hormone level
Serum level of PYY
Time frame: After one month of lipid overnutrition
This study is completed, as verified in May 2011. You cannot join it, but the record below documents what was studied.
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