A Phase 2 interventional study of Intensive language therapy and Intensive language therapy in Post-Stroke Chronic Aphasia and Anomia (Word-retrieval Impairment), sponsored by Charite University, Berlin, Germany. Status unknown at 1 site in Germany. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2013-08-27.
Sponsored by Charite University, Berlin, Germany · Phase 2, Interventional, and Treatment
The purpose of this study is to determine if non-invasive electrical brain stimulation can enhance the out of intensive language therapy in chronic aphasia
Stroke is the leading cause of death and disability worldwide. Given the increasing average lifespan worldwide, the incidence and prevalence of patients with stroke will dramatically increase in the future. One of the most frequent and devastating conditions after stroke is aphasia, which affects language production and comprehension. High-frequent intensive speech-and-language therapy is currently the treatment of choice in chronic aphasia. However, despite its general effectiveness, treatment effect sizes are only low to moderate. Thus, there is a pressing need to explore novel training-adjuvant therapies to enhance treatment efficacy. Moreover, very little is known about the neurobiology of treatment-induced recovery in chronic aphasia. This is the prerequisite to improve existing and/or develop new treatment paradigms.
Thus, in the present project we aim to assess whether the outcome of intensive language training can be enhanced by adjuvant non-invasive brain stimulation. We will be using anodal transcranial direct current stimulation (atDCS) that has previously been shown to enhance (a) language and motor learning in healthy subjects and (b) motor recovery in stroke patients. Specifically, in a longitudinal group comparison design, two matched groups of patients with chronic anomia will receive two weeks of intensive language training with or without atDCS. Treatment effects will be assessed immediately after the two week intervention period and several months after the end of the training. We will also use functional and structural magnetic resonance imaging (MRI) to elucidate language network changes in the two groups.
47 studies on the registry are indexed under Anomia; 9 are open to participants now.
This study's planned enrollment of 40 is above the median of 24 across 43 interventional studies indexed under Anomia.
Browse Anomia studies →Charite University, Berlin, Germany is the lead sponsor of 857 studies on the registry; 129 are open to participants now.
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Exclusion Criteria:
Behavioral: Intensive language therapy
Behavioral: Intensive language therapy
2 weeks of daily computerized naming training, daily, 3 hours
2 weeks of daily computerized naming training, daily, 3 hours
Boston Naming Test
Time frame: Change of naming score from baseline (day 1 of study) to immediately after 2-week intervention period (post-testing)
Boston Naming Test
The follow-up will be administered to assess the stability of the treatment gains
Time frame: Change of naming score from post-testing (after end of intervention) to 3 months after the intervention (follow-up)
Naming performance during functional magnetic resonance scanning
assessed during overt picture naming task
Time frame: Change of naming score from baseline (day 1 of study) to immediately after 2-week intervention period (post-testing)
Naming performance during functional magnetic resonance imaging
assessed during overt picture naming task
Time frame: Change of naming score from post-testing (after end of intervention) to 3 months after the intervention (follow-up)
This study is status unknown, as verified in Aug 2013. You cannot join it, but the record below documents what was studied.
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Charite University, Berlin, Germany →