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Status unknownNCT01198808Updated Jan 18, 2012

Tumorspecific T-cell Immunity in Bladder Cancer as Prognostic Marker

An observational study in Bladder Cancer, sponsored by Technical University of Munich. Status unknown at 1 site in Germany. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-01-18.

Sponsored by Technical University of Munich · Observational

The sponsor has not verified this record recently (last verified Jan 2012), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50
Ages
18 Years to 90 Years
Sex
All
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Study summary

Bladder cancer is generally susceptible to immunotherapeutic measures. The investigators will characterize 40 patients with muscle-invasive bladder cancer regarding the existence and frequency of tumorspecific T-cells and regulatory T cells. The found data will be correlated to clinical data such as the cancer-specific survival and the response to chemotherapy.

It is hypothesized that those patients with a high number of Tregs and no tumor-specific T-cells have a worse prognosis.

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Conditions studied

  • Bladder Cancer

Keywords

  • Bladder cancer
  • chemotherapy
  • T cells
  • Immunotherapy
  • Tumor-specific immunity in bladder cancer
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In context

Urinary Bladder Neoplasms

1,616 studies on the registry are indexed under Urinary Bladder Neoplasms; 421 are open to participants now.

This study's planned enrollment of 50 is below the median of 180 across 374 observational studies indexed under Urinary Bladder Neoplasms.

Browse Urinary Bladder Neoplasms studies →

Lead sponsor

Technical University of Munich is the lead sponsor of 315 studies on the registry; 55 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

The study population will consist of patients with muscle-invasive bladder cancer, who are referred to the university hospital: Krankenhaus rechts der Isar der Technischen Universität München

Inclusion criteria

  • Histologically confirmed muscle-invasive urothelial carcinoma
  • Age > 18 years
  • Hemoglobin > 10g/dl
  • Signed Informed Consent
  • Karnofsky index \< 70%

Exclusion criteria

Exclusion Criteria:

  • Clinically relevant second malignancy
  • Severe comorbidities (e.g. NYHA III, end-stage renal disease)
  • Chronic infectious disease (HIV, Tuberculosis)
  • Immunosupression
  • Severe psychiatric diseases
  • Blood donation in the last 4 weeks
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50 participants (estimated)
Biospecimen retention
Samples without dna
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Study locations

1 site
  • Urologische Klinik der Technischen Universität München
    Munich, Bavaria 81675, Germany
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 18, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01198808
Lead sponsor
Technical University of Munich
Responsible party
Sponsor
First posted
Sep 10, 2010
Start date
Aug 2010
Primary completion
Dec 2011
Last update
Jan 18, 2012

Study contacts

Thomas Horn, MD
principal investigator · Department of Urology, Technische Universität München

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2012. You cannot join it, but the record below documents what was studied.

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