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CompletedNCT01179204Updated Sep 26, 2012

Prediction of Pain in Total Knee Arthroplasty

An observational study in Pain, Postoperative, sponsored by Hvidovre University Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-09-26.

Sponsored by Hvidovre University Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

In this consecutive, prospective cohort study trial the investigators evaluate if preoperative pain response upon heat stimulation is predictive for acute and subacute postoperative pain after total knee arthroplasty.

Read the detailed description

The preoperative heat stimulation consists of short and long tonic heat stimulation. Pain response is evaluated with an electronic visual analog scale.

Furthermore the investigators evaluate other factors possibly predictable for acute and subacute postoperative pain after total knee arthroplasty - demographic factors, preoperative pain related factors, psychosocial factors (Hospital Anxiety and Depression Scale and Pain Catastrophizing Scale).

02

Conditions studied

  • Pain, Postoperative

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03

In context

Pain, Postoperative

5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.

This study's enrollment of 100 is close to the median of 102 across 608 observational studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

Hvidovre University Hospital is the lead sponsor of 295 studies on the registry; 21 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients operated with total knee arthroplasty (TKA)

Inclusion criteria

  • Ethnic danes, above 18 years and able to give informed consent scheduled for primary, unilateral total knee arthroplasty.

Exclusion criteria

Exclusion Criteria:

  • Bilateral / revision arthroplasty
  • Disease affection central or peripheral nerve function
  • Alcohol and medical abuse
  • Daily use of opioids or glucocorticoids
  • Malignancy
  • BMI > 40
  • Depression
  • Dementia or other cognitive dysfunction
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Patiens operated with TKA

    Procedure: Preoperative heat stimulation

Interventions

  • ProcedurePreoperative heat stimulation

    Preoperative short and long tonic heat stimulation

06

What researchers measure

Primary outcomes

  1. Cumulated pain (from 0-24 hours after surgery)

    Pain during walk 5 m (VAS)

    Time frame: 24 hours

Secondary outcomes

  1. Cumulated pain (from day 1 to day 7 after surgery)

    Time frame: 7 days

  2. Pain at day 14 after surgery

    Time frame: 14 days

  3. Pain at day 30 after surgery

    Time frame: 30 days

07

Study locations

1 site
  • Hvidovre University Hospital
    Copenhagen, Hvidovre 2650, Denmark
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 26, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01179204
Lead sponsor
Hvidovre University Hospital
Responsible party
Troels Haxholdt Lunn (MD, Hvidovre University Hospital) — Principal investigator
First posted
Aug 11, 2010
Start date
Aug 2010
Primary completion
Sep 2011
Completion
Sep 2011
Last update
Sep 26, 2012

Study contacts

Troels H. Lunn, M.D
principal investigator · Hvidovre University Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2012. You cannot join it, but the record below documents what was studied.

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