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CompletedNCT01160185Updated Jul 12, 2010

Meta-analysis of Efficacy of Topotecan

An observational study in Cervical Intraepithelial Neoplasia, sponsored by GlaxoSmithKline. Completed. Open to female participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2010-07-12.

Sponsored by GlaxoSmithKline · Observational

Study type
Observational
Time perspective
Retrospective
Enrollment
1
Ages
21 Years and older
Sex
Female
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Study summary

This meta-analysis was conducted to investigate the efficacy of Topotecan and other treatments for recurrent and stage IVB carcinoma of the cervix

Read the detailed description

Studies included in the meta-analysis were: GOG-0179, GOG-0204 \& GOG-0169

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Conditions studied

  • Cervical Intraepithelial Neoplasia
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In context

Uterine Cervical Dysplasia

367 studies on the registry are indexed under Uterine Cervical Dysplasia; 70 are open to participants now.

This study's enrollment of 1 is below the median of 435 across 102 observational studies indexed under Uterine Cervical Dysplasia.

Browse Uterine Cervical Dysplasia studies →

Lead sponsor

GlaxoSmithKline is the lead sponsor of 3,647 studies on the registry; 118 are open to participants now.

Of its 264 completed or terminated interventional studies of FDA-regulated products, 239 (91%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
21 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The search was designed to identify all clinical data published since the Cancer Care Ontario systematic review in 2006. The Cancer Care Ontario systematic review searched MEDLINE (1966 to February 2006), EMBASE (1980 to February 2006), the Cochrane Library (Cochrane Database of Systematic Reviews (2006 Issue 1), and Cochrane Controlled Trials Register (2006 Issue 1)), the Canadian Medical Association Infobase, and the National Guidelines Clearinghouse. The conference proceedings of the American Society of Clinical Oncology (1995-2005) and the European Society of Medical Oncology (2002-2005) were also searched. The search was conducted on 18 December 2008.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Randomised Clinical Trials or systematic reviews or meta-analyses
  • Treatment with topotecan or platinum-based single and combination regimens in female patients of any race with cancer of the cervix recurrent after radiotherapy or stage IVB disease

Exclusion criteria

Exclusion Criteria:

  • None
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Study design

Time perspective
Retrospective
Enrollment
1 participant (actual)

Groups and cohorts

  • cisplatin

    Drug: cisplatin

  • cisplatin + topotecan

    Drug: cisplatin · Drug: topotecan

  • cisplatin + paclitaxel

    Drug: paclitaxel · Drug: cisplatin

Interventions

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What researchers measure

Primary outcomes

  1. Survival

    Time frame: 12 months

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Study locations

No study locations are listed for this record.

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Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jun 2009, a primary completion of Jul 2009 and a completion of Jul 2009. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 8, 2010
First posted
Jul 12, 2010
Start
Jun 2009
Primary completionActual
Jul 2009
CompletionActual
Jul 2009
Last update
Jul 12, 2010
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 12, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01160185
Lead sponsor
GlaxoSmithKline
First posted
Jul 12, 2010
Start date
Jun 2009
Primary completion
Jul 2009
Completion
Jul 2009
Last update
Jul 12, 2010

Study contacts

GSK Clinical Trials
study director · GlaxoSmithKline
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2010. You cannot join it, but the record below documents what was studied.

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