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CompletedNCT01143376Updated Apr 20, 2017

High-intensity Intermittent Training for Obese Individuals

An interventional study of High intensity training and short springs in Obesity, sponsored by Norwegian University of Science and Technology. Completed at 1 site in Norway. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-04-20.

Sponsored by Norwegian University of Science and Technology · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
46
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
All
01

Study summary

The most appropriate and effective exercise interventions for weight loss remain a matter of continued discussion and there is a need to identify sustainable exercise programs which successfully promote weight loss and benefit health.

The primary objective of this study is to determine if high-intensity intermittent sprinting (HIIS) produces better results in terms of reducing metabolic and cardiovascular risk factors, with special emphasis to fat mass loss and insulin sensitivity in "healthy" obese volunteers compared with an iso-caloric program of moderate-intensity continuous cycling (MICC) (control condition following the international recommendations). We will also assess the impact of short duration sprints (SDS) in the above factors and to understand the potential mechanisms behind different outcomes among training programs.

The overall hypothesis is that HIIS will lead to a greater reduction in metabolic and cardiovascular risk factors compared with MICC in healthy obese volunteers and that SDS will produce similar improvements in cardiovascular risk factors as the longer duration HIIS

Read the detailed description

Participants will be randomized to one of three groups: HIIS (8s sprint:12s rest) or MICC (control group) iso-caloric protocols (for the duration needed to induce a 250 kcal energy deficit) or SDS (8s sprint:12s rest) for 10 minutes for 12 weeks. The intervention groups will be matched for age, BMI and male/females ratio and participants will be asked not to change their normal diet throughout the study.

Before and after the exercise intervention (12 weeks), participants will perform the following assessments:

  1. Three-day food diaries
  2. Anthropometric measurements (weight, height, waist and hips) using standard procedures;
  3. Body composition using dual energy x-ray absorptiometry (DEXA)
  4. RMR and resting respiratory exchange ratio (RER) using indirect calorimetry;
  5. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery using vascular ultrasound according to current guidelines;
  6. Maximal oxygen uptake (VO2max) and fat oxidation, cardiac output and left ventricular function during exercise using a cycle ergometer;
  7. Muscle and fat biopsies
  8. Fasting and postprandial release of appetite related hormones (and subjective feelings of hunger/fullness using visual analogue scales - VAS).
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Conditions studied

  • Obesity

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Keywords

  • Obesity
  • exercise
  • body composition
  • insulin sensitivity
  • appetite
  • food intake
03

In context

Obesity

6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.

This study's enrollment of 46 is below the median of 78 across 4,878 interventional studies indexed under Obesity.

Browse Obesity studies →

Lead sponsor

Norwegian University of Science and Technology is the lead sponsor of 487 studies on the registry; 52 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • weight stable on the last three months,
  • not currently dieting to lose weight
  • inactive lifestyle.

Exclusion criteria

Exclusion Criteria:

  • History of endocrine/cardiovascular/pulmonary/kidney disease,
  • anaemia,
  • gout,
  • depression or other psychological disorders,
  • eating disorders,
  • drug or alcohol abuse within the last two years
  • current medication known to affect appetite or induce weight loss.
  • planned surgery during the study period
  • participation in another research study
  • restraint score derived from the TFEQ>12
  • post-menopausal women
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
46 participants (actual)

Study arms

  • Active comparator
    Moderate intensity exercise

    Moderate intensity exercise

    Behavioral: Moderate intensity exercise

  • Experimental
    High Intensity training

    High Intensity intermittent training

    Behavioral: High intensity training

  • Experimental
    Short springs

    short springs training

    Behavioral: short springs

Interventions

  • BehavioralHigh intensity training

    high-intensity intermittent sprinting (HIIS) (8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

  • Behavioralshort springs

    short duration sprints (SDS)(8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

  • BehavioralModerate intensity exercise
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What researchers measure

Primary outcomes

  1. Changes in body composition

    Body composition assessed by DEXA

    Time frame: Baseline and after 12 weeks of training

Secondary outcomes

  1. Changes in insulin sensitivity

    Insulin will be measured in fasting and for 3h after a test meal

    Time frame: Baseline and after 12 weeks of training

07

Study locations

1 site
  • Norwegian University of Science and Technology
    Trondheim, 7489, Norway
08

References and documents

Publications

  • Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals. Int J Sport Nutr Exerc Metab. 2016 Jun;26(3):197-204. doi: 10.1123/ijsnem.2015-0078. Epub 2015 Oct 19. PubMed 26479856 ↗
  • Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B. High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. Med Sci Sports Exerc. 2017 Sep;49(9):1851-1858. doi: 10.1249/MSS.0000000000001296. PubMed 28398946 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 20, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01143376
Lead sponsor
Norwegian University of Science and Technology
Collaborators
Helse Midt-Norge
Responsible party
Sponsor
First posted
Jun 14, 2010
Start date
May 2010
Primary completion
Dec 2012
Completion
Jan 2014
Last update
Apr 20, 2017

Study contacts

Catia Martins, PhD
principal investigator · Norwegian University of Science and Technology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.

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