An observational study in Glioma, sponsored by Merck Sharp & Dohme LLC. Completed. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2015-10-12.
Sponsored by Merck Sharp & Dohme LLC · Observational
This study will evaluate the test-retest repeatability of lactate and other metabolites measured by single voxel magnetic resonance spectroscopy (MRS) and multi-voxel magnetic resonance spectroscopic imaging experiments (MRSI) in tumor tissue in patients radiographically diagnosed with glioma.
These measurements will test whether the concentration of lactate in tumor will be higher than the concentration of lactate in normal tissue of the same patient.
1,397 studies on the registry are indexed under Glioma; 351 are open to participants now.
This study's enrollment of 8 is below the median of 88 across 238 observational studies indexed under Glioma.
Browse Glioma studies →Merck Sharp & Dohme LLC is the lead sponsor of 2,114 studies on the registry; 133 are open to participants now.
Of its 489 completed or terminated interventional studies of FDA-regulated products, 362 (74%) have results posted.
Counted across the registry records on this site, refreshed daily.
Male and female patients aged 18-70 years old with newly diagnosed operable glioma of grade II or higher
Exclusion Criteria:
Male and female patients aged 18-70 years old with newly diagnosed operable glioma of grade II or higher
The test-retest repeatability of lactate and other metabolites when measured by multi-voxel MRSI in tumor tissue
Time frame: 90 minutes
The test-retest repeatability of lactate and other metabolites when measured by single voxel MRS
Time frame: 90 minutes
The geometric mean fold rise (GMFR) in the concentrations of lactate and each of the other metabolites for tumor/normal tissue
Time frame: 90 minutes
The test-retest repeatability of lactate and other metabolites when measured by multi-voxel MRSI in normal tissue
Time frame: 90 minutes
True geometric mean ratio (GMR) of the MRSI/SV MRS concentration values
Time frame: 90 minutes
The mean levels of each of the metabolites will be summarized by tumor grade and type
Time frame: 90 minutes
The correlation between in vivo (measured by MRSI) and in vitro levels of lactate and other metabolites in tumors
Time frame: 90 minutes
The within day and between day standard deviations for each metabolite
Time frame: 90 minutes
No study locations are listed for this record.
This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.
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Merck Sharp & Dohme LLC