An observational study in Obesity, Insulin Resistance and Diabetes Mellitus Type 2, sponsored by Aristotle University Of Thessaloniki. Completed at 1 site in Greece. Open to participants aged 2 Years to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-05-19.
Sponsored by Aristotle University Of Thessaloniki · Observational
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
So far apelin has been reported to be involved in the pathophysiology of various heart diseases such as cardiomyopathies and heart failure. According to recent reports in adults apelin seems to be associated with impaired glucose metabolism, particularly in newly diagnosed diabetes type 2 patients. Obesity is associated with insulin resistance and compensatory hyperinsulinemia leading to diabetes mellitus type 2 even in youngsters. The researchers will try to investigate the role of this new adipokine in order to early detect and to prevent similar entities in childhood obesity.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's enrollment of 180 is above the median of 80 across 339 observational studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →Aristotle University Of Thessaloniki is the lead sponsor of 274 studies on the registry; 56 are open to participants now.
Counted across the registry records on this site, refreshed daily.
40 obese children 40 obese adolescents 50 lean children 50 lean adolescents
Exclusion Criteria:
obese subjects according to International Obesity Task Force criteria
Serum Apelin Levels
Apelin levels were measured in serum of participants, in fasting state
Time frame: First day after enrollment and after 8-hours of night fasting, at approximately 8:00 pm in the morning
Frequency of G212A Polymorphism of Apelin Receptor in Obese Children and Adolescents
Number of participants with Apelin Receptor Gene G212A polymorphism by genotype group
Time frame: First day after enrollment
| Milestone | Obese | Lean |
|---|---|---|
| Started | 90 | 90 |
| Completed | 90 | 90 |
| Not completed | 0 | 0 |
Apelin levels were measured in serum of participants, in fasting state
| ng/ml | Obese | Lean |
|---|---|---|
| Serum Apelin Levels | 1.45 (0.63 to 4.54) | 1.91 (0.55 to 4.71) |
Number of participants with Apelin Receptor Gene G212A polymorphism by genotype group
| participants | Obese Group |
|---|---|
| GG | 48 |
| AA | 7 |
| GA | 35 |
Collected over This is a cross-sectional non intervantional, observation study. Time for reporting adverse events was the first day after enrollment, during which blood samples were collected.. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Obese | — | 0/90 (0%) | 0/90 (0%) |
| Lean | — | 0/90 (0%) | 0/90 (0%) |
| Age, Continuous(years) | Obese | Lean | Total |
|---|---|---|---|
| Median | 11.6 (2.6 to 16.5) | 11.7 (3.3 to 17.8) | 11.6 (2.6 to 17.8) |
| Sex: Female, Male(Participants) | Obese | Lean | Total |
|---|---|---|---|
| Female | 56 | 47 | 103 |
| Male | 34 | 43 | 77 |
| Region of Enrollment(participants) | Obese | Lean | Total |
|---|---|---|---|
| Greece | 90 | 90 | 180 |
This study is completed, as verified in Apr 2016. You cannot join it, but the record below documents what was studied.
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Aristotle University Of Thessaloniki