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CompletedNCT01120730Updated May 11, 2010

Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury

A Phase 3 interventional study of fluid resuscitation and Fluid resuscitation in Survival and Renal Failure, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2010-05-11.

Sponsored by University of Zurich · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

HES 200/0.5 10% is equal to ringers lactat solution.

Read the detailed description

30 Patients were enrolled to the study, either to the hyperoncotic HES 200/0.5 (10%) group or to the crystalloids only group. After a treatment protocol of 72 hours we collected data about complications like pulmonary failure and abdominal compartment syndrome. Furthermore, we addressed the question of incidence of mortality and renal failure.

02

Conditions studied

  • Survival
  • Renal Failure
03

In context

Renal Insufficiency

1,995 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.

This study's enrollment of 28 is below the median of 43 across 1,504 interventional studies indexed under Renal Insufficiency.

Browse Renal Insufficiency studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • All burn victims with burned surface area bigger than 20%

Exclusion criteria

Exclusion Criteria:

  • Pregnancy
05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
28 participants (actual)

Study arms

  • Active comparator
    HES

    Fluid resuscitation with HES

    Drug: fluid resuscitation

  • Placebo comparator
    ringers lactat

    Standard treatment

    Drug: Fluid resuscitation

Interventions

  • Drugfluid resuscitation

    fluid resuscitation with HES

  • DrugFluid resuscitation

    Fluid resuscitation in standardized fashion

06

What researchers measure

Primary outcomes

  1. Intensive care unit mortality

    28 days

    Time frame: 28 days

Secondary outcomes

  1. fluid amount during the first 72 hours

    Fluid resuscitation after burn

    Time frame: 28 days

07

Study locations

1 site
  • University Hospital Zurich
    Zurich, 8091, Switzerland
08

References and documents

Publications

  • Bechir M, Puhan MA, Neff SB, Guggenheim M, Wedler V, Stover JF, Stocker R, Neff TA. Early fluid resuscitation with hyperoncotic hydroxyethyl starch 200/0.5 (10%) in severe burn injury. Crit Care. 2010;14(3):R123. doi: 10.1186/cc9086. Epub 2010 Jun 28. PubMed 20584291 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 11, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01120730
Lead sponsor
University of Zurich
First posted
May 11, 2010
Start date
Apr 1997
Primary completion
Sep 1998
Completion
Mar 2009
Last update
May 11, 2010

Study contacts

Markus Béchir, md
principal investigator · University of Zurich

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2010. You cannot join it, but the record below documents what was studied.

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