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CompletedNCT01113866Updated May 4, 2010

Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients

An observational study in Heart Failure, sponsored by University of Parma. Completed at 1 site in Italy. Per ClinicalTrials.gov, last updated 2010-05-04.

Sponsored by University of Parma · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
124
Sex
All
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Study summary

Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.

Read the detailed description

Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).

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Conditions studied

  • Heart Failure

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03

In context

Heart Failure

5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.

This study's enrollment of 124 is below the median of 200 across 1,679 observational studies indexed under Heart Failure.

Browse Heart Failure studies →

Lead sponsor

University of Parma is the lead sponsor of 76 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

heart failure patients with preserved or impaired systolic function

Inclusion criteria

  • symptomatic congestive heart failure lasting at least six months
  • reduced exercise tolerance
  • impaired or preserved left ventricular ejection fraction
  • cardiomegaly

Exclusion criteria

Exclusion Criteria:

  • acute infection
  • rheumatoid or other autoimmune diseases
  • primary cachectic states (cancer, thyroid disease, severe liver disease)
  • severe chronic lung disease
  • neuromuscular disorders
  • myocardial infarction within the previous 20 weeks
  • diabetes mellitus
  • chronic renal failure (serum creatinine level > 2.0 mg/dl, >177 micromol/L)
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
124 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • heart failure
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Study locations

1 site
  • Università di Parma
    Parma, 43126, Italy
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01113866
Lead sponsor
University of Parma
First posted
Apr 30, 2010
Start date
Oct 1998
Primary completion
May 2003
Completion
Jan 2009
Last update
May 4, 2010

Study contacts

Aderville Cabassi, MD
principal investigator · University of Parma

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2009. You cannot join it, but the record below documents what was studied.

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