CompletedNCT01107314Updated Jan 17, 2018

Vasopressin Deficiency in Hemorrhagic Shock

An observational study in Body Response to Trauma, sponsored by The University of Texas Health Science Center at San Antonio. Completed at 1 site in United States. Open to participants aged 18 Years to 98 Years. Per ClinicalTrials.gov, last updated 2018-01-17.

Sponsored by The University of Texas Health Science Center at San Antonio · Observational

Study type: Observational
Model: Other
Time perspective: Prospective
Enrollment: 81
Ages: 18 Years to 98 Years
Sex: All

Study summary

In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Read the detailed description

This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.

Conditions studied

Body Response to Trauma

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In context

Diabetes Insipidus, Neurogenic

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Lead sponsor

The University of Texas Health Science Center at San Antonio is the lead sponsor of 435 studies on the registry; 88 are open to participants now.

Of its 62 completed or terminated interventional studies of FDA-regulated products, 31 (50%) have results posted.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 98 Years
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

observational study - trauma patients admitted to University Hospital

Inclusion criteria

Patient is a male or female patient presumed to be at least 18 years of age;
Patient has a reported or actual systolic blood pressure \< 90 mmHg within 1 hour of arrival to the Emergency Room;
Patient has clinical evidence of acute traumatic injury;

Exclusion criteria

Exclusion Criteria:

Patient is asystolic or requires CPR prior to arrival;
Patient was transferred from an outside facility
Patient known to be pregnant
Patient known to be prisoner

Study design

Observational model: Other
Time perspective: Prospective
Enrollment: 81 participants (actual)

Groups and cohorts

trauma patient
SBP less than 90mmHg
Other: Phlebotomy

Interventions

OtherPhlebotomy
Blood draws (total 48 cc blood)

Study locations

1 site

UTHSCSA
San Antonio, Texas 78229-3900, United States

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jan 17, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01107314
Lead sponsor: The University of Texas Health Science Center at San Antonio
Responsible party: Sponsor
First posted: Apr 20, 2010
Start date: Feb 2010
Primary completion: Apr 30, 2011
Completion: Apr 30, 2011
Last update: Jan 17, 2018

Study contacts

Stephen M Cohn, MD

principal investigator · The University of Texas Health Science Center at San Antonio

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2012. You cannot join it, but the record below documents what was studied.

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