An observational study in Heart Failure, sponsored by University Medical Center Groningen. Status unknown at 2 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-06-11.
Sponsored by University Medical Center Groningen · Observational
The investigators hypothesize that chronic heart failure is associated with a general stem cell dysfunction, which translates into reduced paracrine function of adult stem cells from patients with chronic heart failure as compared to patients with preserved systolic function.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's planned enrollment of 125 is below the median of 200 across 1,679 observational studies indexed under Heart Failure.
Browse Heart Failure studies →University Medical Center Groningen is the lead sponsor of 609 studies on the registry; 174 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Man and woman, undergoing cardiothoracic surgery, older than 18 years of age, with and without preserved left ventricular ejection fraction (LVEF \<40% and >40%). Controls are man and women, older than 18 years of age, scheduled for orthopaedic surgery without a history of cardiac disease.
For all participants:
Male and female older than 18 years of age.
For the cardiac patients:
A known left ventricular ejection fraction, either assessed by echocardiography, MUGA or MRI. If LVEF \<40% a subject will be assigned to the chronic heart failure group, if LVEF >40% a subject will be assigned to the control group.
For the non-cardiac patients:
Exclusion Criteria:
Legally incompetent adults, for which reason what so ever.
For the non-cardiac patients:
Patients without heart failure undergoing open chest surgery
Other: Surgery
Patients without heart failure undergoing orthopedic surgery
Other: Surgery
Patients with heart failure undergoing open chest surgery.
Other: Surgery
Patients undergoing surgery for either cardiac surgery or orthopedic surgery
Paracrine properties of bone marrow cells from patients with heart failure
To compare the paracrine properties of bone marrow-derived stem cells harvested from patients suffering chronic heart failure vs healthy subjects. In particular, we aim to determine if the cytoprotective, pro-angiogenic and anti-fibrotic effects mediated by bone marrow stem cells of heart failure patients are similar to those from healthy patients.
Time frame: 1 day
To study preconditioning of different bone marrow stem cells with different cytokines
Time frame: 1 day
To study in detail the temporal and spatial expression of paracrine factors in bone marrow stem cells in vitro, and to study the differences between bone marrow stem cells from patients with and without chronic heart failure
Time frame: 1 day
To evaluate potential molecular mechanisms involved
Time frame: 1 day
To find mechanisms to enhance expansion of different bone marrow stem cells in vitro
Time frame: 1 day
This study is status unknown, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.
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University Medical Center Groningen