CompletedNCT01029379Updated Mar 4, 2013

Pharmacogenetics of Propofol and Depth of Anesthesia

An observational study in Anesthesia and Propofol, sponsored by University Hospital, Linkoeping. Completed at 1 site in Sweden. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2013-03-04.

Sponsored by University Hospital, Linkoeping · Observational

Study type: Observational
Model: Cohort
Time perspective: Prospective
Enrollment: 100
Ages: 18 Years to 50 Years
Sex: All

Study summary

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia.

The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.

Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.

200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.

Conditions studied

Anesthesia
Propofol

Keywords

propofol
depth of anesthesia
pharmacogenetics
Depth of anesthesia in correlation to plasma concentrations of propofol

In context

Lead sponsor

University Hospital, Linkoeping is the lead sponsor of 118 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 50 Years
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

200 patients, ASA classification 1 planned for elective surgery of at least 30 minutes duration

Inclusion criteria

Healthy caucasian patents,
(ASAclassification 1) planned for elective surgery,
with body mass index 20-30,
free from analgetic drug > 12 hours prior to anesthesia

Exclusion criteria

Exclusion Criteria:

Pregnancy,
Smoking,
allergy to propofol or peanuts,
alcohol abuse,
non-caucasian

Study design

Observational model: Cohort
Time perspective: Prospective
Enrollment: 100 participants (actual)

Groups and cohorts

200 patients,ASA 1

What researchers measure

Primary outcomes

EEG pattern in correlation to clinical anesthesia
EEG pattern in correlation to clinical anesthesia
Time frame: 20120101

Study locations

1 site

Department of Anesthesia and Intensive Care
Kalmar, Sweden

References and documents

Publications

Khan MS, Zetterlund EL, Green H, Oscarsson A, Zackrisson AL, Svanborg E, Lindholm ML, Persson H, Eintrei C. Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment. Basic Clin Pharmacol Toxicol. 2014 Dec;115(6):565-70. doi: 10.1111/bcpt.12277. Epub 2014 Jul 19. PubMed 24891132 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Mar 4, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01029379
Lead sponsor: University Hospital, Linkoeping
Responsible party: Anna Oscarsson (Dr, University Hospital, Linkoeping) — Principal investigator
First posted: Dec 10, 2009
Start date: Jan 2010
Primary completion: Feb 2013
Completion: Feb 2013
Last update: Mar 4, 2013

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2013. You cannot join it, but the record below documents what was studied.

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