An interventional study of Magnetic Resonance Imaging and Diffusion Tensor Imaging in Brain Tumor, sponsored by Abramson Cancer Center at Penn Medicine. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-12-11.
Sponsored by Abramson Cancer Center at Penn Medicine · Not applicable, Interventional, and Diagnostic
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying magnetic resonance imaging in response to radiation therapy in patients with high grade glioma.
Detailed DescriptionOBJECTIVES:
I. To develop a multimodality statistical model to act as a surrogate marker scheme of early changes in high grade glioma patients undergoing radiation therapy, using conventional MRI, MR diffusion tensor imaging, perfusion, permeability, and spectroscopic imaging while incorporating the radiation dose calculations delivered locally and the results of a clinical questionnaire into the model.
II. To assess treatment response to tumor and normal tissue changes. OUTLINE: Patients undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6, and then 4-6 weeks after completion of radiation therapy.
1,960 studies on the registry are indexed under Brain Neoplasms; 516 are open to participants now.
This study's planned enrollment of 10 is below the median of 40 across 1,458 interventional studies indexed under Brain Neoplasms.
Browse Brain Neoplasms studies →Abramson Cancer Center at Penn Medicine is the lead sponsor of 446 studies on the registry; 86 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 14 (44%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6 and then 4-6 weeks after completion of radiation therapy.Patients undergo MRI imaging at baseline, weeks 1, 2, 3, 5, 6 and then 6 weeks after radiation therapy.
Procedure: Magnetic Resonance Imaging · Procedure: Diffusion Tensor Imaging · Procedure: Magnetic Resonance Spectroscopic Imaging · Procedure: Dynamic Contract-Enhanced magnetic resonance imaging · Procedure: Diffusion-weighted magnetic resonance imaging
Also known as: MRI,NMR imaging, NMRI, nuclear magnetic resonance imaging
Also known as: 1H-nuclear magnetic resonance spectroscopic imaging, Proton Magnetic Resonance Spectroscopic Imaging
Also known as: DCE-MRI
Also known as: diffusion-weighted MRI
Early brain tumor response
Early therapeutic-induced changes in normal surrounding brain
This study is completed, as verified in Dec 2012. You cannot join it, but the record below documents what was studied.
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Abramson Cancer Center at Penn Medicine