An interventional study of Hyperinsulinaemia and Losartan in Insulin Resistance and Type 2 Diabetes, sponsored by Institute for Clinical and Experimental Medicine. Completed at 1 site in Czech Republic. Open to male participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-10-18.
Sponsored by Institute for Clinical and Experimental Medicine · Not applicable, Interventional, and Basic science
The study aims to investigate the effect of acute angiotensin receptor blockade on insulin action/insulin resistance and expressions of selected adipocytokines in subcutaneous adipose tissue in insulin-resistant subjects with type 2 diabetes and healthy controls.
Hypothesis: Changes in adipocytokine concentrations and/or expressions and different reactions to acute in vivo induced hyperinsulinemia and angiotensin receptor blockade will be found in patients with type 2 diabetes compared to healthy subjects. A significant relationships between insulin sensitivity and selected adipokines and intracellular fat content and high energy phosphates in soleus muscle will be documented in healthy individuals, while no significant relation will be found in patients with type 2 diabetes.
10-15 patients with type 2 diabetes and 10-15 healthy control subjects will be examined on an outpatient basis. The following examination will be carried out in each subject after 12 hrs fasting:
Before (0 min), at 30 min and in the end of studies c) and d) the blood samples will be taken and biopsies of subcutaneous abdominal adipose tissue will be done.
10,926 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.
This study's enrollment of 23 is below the median of 80 across 8,368 interventional studies indexed under Diabetes Mellitus.
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Exclusion Criteria:
Type 2 Diabetes
Healthy volunteers
Hyperinsulinaemic (1 mIU/kg/min) euglycaemic (5 mmol/l) clamp
Procedure: Hyperinsulinaemia
Procedure: Hyperinsulinaemia · Drug: Losartan
Infusion of Saline as a volume control intervention
Drug: Saline
Hyperinsulinaemic (1 mIU/kg/min) euglycaemic (5 mmol/l) clamp
Acute administration of losartan 200mg total prior to clamp
Infusion of Saline as a volume control intervention
insulin sensitivity measured as glucose disposal during clamp
Time frame: 4 hours
plasma adipokines and their expressions in SAT
Time frame: at 0 and 240 min of the clamp
This study is completed, as verified in Nov 2009. You cannot join it, but the record below documents what was studied.
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Institute for Clinical and Experimental Medicine