An interventional study of Sodium thiosulfate in Renal Failure, sponsored by Insel Gruppe AG, University Hospital Bern. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-10-13.
Sponsored by Insel Gruppe AG, University Hospital Bern · Not applicable, Interventional, and Treatment
The pharmacokinetics of sodium thiosulfate in humans with different degrees of renal failure and in healthy volunteers will be after two single shot applications.
Two single shot applications of i.v. sodium thiosulfate will be given to dialysis patients. One application will be given immediately before a dialysis session and the second dose will be given after the consecutive dialysis session.
In healthy volunteers sodium thiosulfate will be given only once. In both groups, dialysis patients and healthy volunteers, blood and urinary/dialysate samples will be collected at defined time points.
1,994 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.
This study's enrollment of 19 is below the median of 43 across 1,503 interventional studies indexed under Renal Insufficiency.
Browse Renal Insufficiency studies →Insel Gruppe AG, University Hospital Bern is the lead sponsor of 724 studies on the registry; 177 are open to participants now.
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Two doses of sodium thiosulfate
Drug: Sodium thiosulfate
One dose of sodium thiosulfate
Drug: Sodium thiosulfate
6g of Sodium Thiosulfate are applicated in a short infusion over a time of 5 min
Also known as: Na2S2O3
Elimination half life in dependence of the degree of renal failure
Time frame: 0, 15, 30, 60, 180 minutes and 24 hours after application
Changes in acid-base parameter after application of sodium thiosulfate
Time frame: 0, 15, 30, 60, 180 minutes and 24 hours after application
This study is completed, as verified in Oct 2011. You cannot join it, but the record below documents what was studied.
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Insel Gruppe AG, University Hospital Bern