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CompletedNCT01008488Updated Dec 23, 2011

Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis

An interventional study of Antibiotic in Colonic Diverticulitis, sponsored by Uppsala University. Completed at 1 site in Sweden. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2011-12-23.

Sponsored by Uppsala University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
600
Allocation
Randomized
Ages
18 Years to 90 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.

The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.

The patients will be randomized to conservative treatment with and without antibiotic therapy.

02

Conditions studied

  • Colonic Diverticulitis

Keywords

  • colonic diverticulitis
  • diverticular disease
  • antibiotic therapy
03

In context

Diverticulitis, Colonic

27 studies on the registry are indexed under Diverticulitis, Colonic; 8 are open to participants now.

This study's enrollment of 600 is above the median of 142 across 10 interventional studies indexed under Diverticulitis, Colonic.

Browse Diverticulitis, Colonic studies →

Lead sponsor

Uppsala University is the lead sponsor of 390 studies on the registry; 86 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • adults with CT sign of acute colonic uncomplicated diverticulitis
  • elevated CRP and LPK
  • Temp.38c or more

Exclusion criteria

Exclusion Criteria:

  • patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
  • pregnancy
  • immunological incompetence and therapy
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

Read whether the line is about a condition or about medicines, and which medicines and doses it means.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
600 participants (actual)

Study arms

  • Active comparator
    Antibiotic

    Drug: Antibiotic

  • No intervention
    No antibiotic

Interventions

  • DrugAntibiotic

    Antibiotic according to local treatment routine against bowel pathogenesis

06

What researchers measure

Primary outcomes

  1. discharge without complications +/- antibiotic therapy

    Time frame: Within 30 days after discharge

Secondary outcomes

  1. to evaluate length of hospital stay, cost and late complications

    Time frame: one year after admission

07

Study locations

1 site
  • The Central Hospital
    Västerås, Västmanland, Sweden
08

References and documents

Publications

  • Chabok A, Pahlman L, Hjern F, Haapaniemi S, Smedh K; AVOD Study Group. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg. 2012 Apr;99(4):532-9. doi: 10.1002/bjs.8688. Epub 2012 Jan 30. PubMed 22290281 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 23, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01008488
Lead sponsor
Uppsala University
Collaborators
Landstinget i Värmland
Responsible party
achabok (MD, Uppsala University) — Principal investigator
First posted
Nov 5, 2009
Start date
Nov 2002
Primary completion
May 2010
Completion
Dec 2010
Last update
Dec 23, 2011

Study contacts

Kenneth Smedh
principal investigator · Center of Clinical Research, Västerås

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2011. You cannot join it, but the record below documents what was studied.

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