An interventional study of Hydrochloric acid (0.15 molar) and Saline in Cough and Healthy Controls, sponsored by University of Manchester. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-06-19.
Sponsored by University of Manchester · Not applicable, Interventional, and Basic science
Central sensitisation is an increase in the excitability of nerves within the central nervous system, which can lead to heightened sensitivity to certain stimuli. This process is involved in some chronic pain conditions e.g. migraines and non-cardiac chest pain. Recent work by our group suggests central sensitisation may be an important mechanism leading to chronic cough.
The main questions in this study include:
In animal studies, acid infusion into the gullet (oesophagus) is able to induce central sensitisation of the cough reflex. Acid infusion into the oesophagus has also been shown to induce central sensitisation in human healthy volunteers, increasing the sensitivity to pain on the front of the chest but this study did not test the the cough reflex. Using human participants, the investigators plan to test whether acid infusion into the oesophagus increases the sensitivity of the cough reflex in healthy volunteers and also patients complaining of chronic cough.
346 studies on the registry are indexed under Cough; 71 are open to participants now.
This study's enrollment of 27 is below the median of 70 across 263 interventional studies indexed under Cough.
Browse Cough studies →University of Manchester is the lead sponsor of 194 studies on the registry; 43 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthy volunteers inclusion:
Chronic Cough Patients inclusion:
Exclusion Criteria:
Other: Hydrochloric acid (0.15 molar)
Other: Saline
Hydrochloric acid (0.15 molar) will be infused in to the lower oesophagus through a distal infusion port located at the tip of an oesophageal stimulation catheter.
Normal saline will be infused in to the lower oesophagus through a distal infusion port located at the tip of an oesophageal stimulation catheter.
Effect of oesophageal acid infusion on cough reflex sensitivity in chronic cough patients compared to healthy controls.
Outcome measures include; cough reflex sensitivity, pain threshold measures, 24 hour objective cough rate
Time frame: baseline, immediatley after infusion, 90 minutes post infusion, 180 minutes post infusion, 24 hours after baseline
This study is completed, as verified in Jun 2013. You cannot join it, but the record below documents what was studied.
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University of Manchester