An interventional study of Ringer's Lactate and Six percent hydroxyethyl starch in Cesarean Section, sponsored by Nanjing Medical University. Completed at 1 site in China. Open to female participants aged 21 Years to 40 Years. Per ClinicalTrials.gov, last updated 2009-09-09.
Sponsored by Nanjing Medical University · Not applicable, Interventional, and Supportive care
Fluid management plays an essential role in cesarean section. In previous study (NCT00488111) the investigators found that prior-epidural anesthesia fluid management produced a more significant role in stabilizing the blood pressure and better prognosis after cesarean delivery than that of the posterior-anesthesia ones. Given epidural anesthesia has a time interval before reaching the best state of anesthesia, so the fluid management also has a relatively adequate time to resuscitation. In reality, spinal anesthesia is used popularly except for the epidural anesthesia, whereas spinal anesthesia would produce more significant fluctuation of the hemodynamics compared with the latter. Herein the investigators proposed whether the prior-spinal anesthesia fluid management also produced similar effect on hemodynamic characteristics to the epidural anesthesia.
Nanjing Medical University is the lead sponsor of 169 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Crystalloid (Ringer's Lactate) was given before spinal anesthesia
Drug: Ringer's Lactate
Crystalloid (Ringer's Lactate) was given after spinal anesthesia
Drug: Ringer's Lactate
Colloid (6% hydroxyethyl starch) was given before spinal anesthesia
Drug: Six percent hydroxyethyl starch
Colloid (6% hydroxyethyl starch) was given after spinal anesthesia
Drug: Six percent hydroxyethyl starch
Ringer's Lactate 8 ml/kg was given intravenously before or after spinal anesthesia in cesarean section
Also known as: Lactated Ringer's solution
Hydroxyethyl starch (6%) was given before or after spinal anesthesia in cesarean section
Also known as: HES/HAES
Rate of hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Recurrence of hypotension after ephedrine or phenylephrine
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Consumption of ephedrine and phenylephrine
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Total volume of colloid or crystalloid
Time frame: Fifteen minutes before anesthesia to 120 min after anesthesia
One-min and 5-min Apgar scores
Time frame: The first and fifth minute after cesarean successful delivery
Oxygen saturation during hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Duration of hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Low umbilical cord pH (artery < 7.20)
Time frame: At the time of successful delivery (0 min)
This study is completed, as verified in Sep 2009. You cannot join it, but the record below documents what was studied.
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Nanjing Medical University