A Phase 4 interventional study of Methylprednisolone and Placebo in Postoperative Pain, Postoperative Nausea and Vomiting and Sleeping Quality, sponsored by Hvidovre University Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-09-26.
Sponsored by Hvidovre University Hospital · Phase 4, Interventional, and Supportive care
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty.
The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.
In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total knee arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after knee arthroplasty.
1,100 studies on the registry are indexed under Vomiting; 134 are open to participants now.
This study's enrollment of 48 is below the median of 107 across 935 interventional studies indexed under Vomiting.
Browse Vomiting studies →Hvidovre University Hospital is the lead sponsor of 295 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Methylprednisolone 125 mg iv pre-operatively
Drug: Methylprednisolone
Saline iv pre-operatively in equivalent volume (placebo)
Drug: Placebo
Methylprednisolone 125 mg iv pre-operatively
Saline iv pre-operatively in equivalent volume (placebo)
Postoperative pain
Time frame: 48 hours + follow up
Postoperative nausea and vomiting (PONV)
Time frame: 48 hours + follow up
Sleeping quality
Time frame: 48 hours + follow up
Inflammatory response
Time frame: 48 hours + follow up
Additional analgetics, antinausea agents and sleeping medicine
Time frame: 48 hours + follow up
Time in hospital
Time frame: Until discharge
Fatigue
Time frame: 48 hours + follow up
This study is completed, as verified in Sep 2012. You cannot join it, but the record below documents what was studied.
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Hvidovre University Hospital