An observational study in Lung Neoplasms and Cachexia, sponsored by AHS Cancer Control Alberta. Terminated at 1 site in Canada. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2016-02-26.
Sponsored by AHS Cancer Control Alberta · Observational
The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.
7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.
This study's enrollment of 12 is below the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →AHS Cancer Control Alberta is the lead sponsor of 182 studies on the registry; 31 are open to participants now.
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Lung cancer patients
Exclusion Criteria:
Lung cancer patients who exhibit abnormalities in lipid measures.
Other: Blood draws · Biological: Oral administration of stable isotope (deuterium) · Procedure: Metabolic rate testing
Up to 4 blood draws will be required, in the amount of about 10 mL each
1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours
Also known as: C/D/N Isotopes, Deuterium Oxide, CAS No: 7789-20-0
Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study.
Rate of hepatic de novo lipogenesis
Time frame: 9 months
Measures of fat transport and availability
Time frame: 9 months
Resting metabolic rate & fat oxidation
Time frame: 9 months
This study is terminated, as verified in Apr 2012. You cannot join it, but the record below documents what was studied.
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AHS Cancer Control Alberta