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CompletedNCT00961935Updated Jan 13, 2016

Pediatric Bipolar Disorder Study at UCLA

An observational study in Bipolar Disorder, sponsored by University of California, Los Angeles. Completed at 1 site in United States. Open to participants aged 7 Years to 17 Years. Per ClinicalTrials.gov, last updated 2016-01-13.

Sponsored by University of California, Los Angeles · Observational

Study type
Observational
Time perspective
Cross-sectional
Enrollment
50
Ages
7 Years to 17 Years
Sex
All
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Study summary

The UCLA Semel Institute for Neuroscience in Los Angeles, CA, is conducting a study looking at similarities and differences in how the brain works between bipolar disorder and attention deficit hyperactivity disorder (ADHD).

Read the detailed description

Children between the ages of 7 and 17 years old, with a diagnosis of Bipolar I, Bipolar II, or Bipolar NOS, are currently being recruited for this study looking at similarities and differences in how the brain works between bipolar disorder and attention deficit hyperactivity disorder (ADHD). The study involves a comprehensive evaluation at intake, cognitive assessment, EEG, and functional MRI, done over the course of 2 or 3 visits. This study does not provide treatment. However, with participants' consent, the assessment information can be shared with the child's clinician or psychiatrist and a letter with the results from cognitive testing can be prepared, which can be useful in school planning. Referrals for treatment can also be provided.

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Conditions studied

  • Bipolar Disorder

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Keywords

  • bipolar disorder
  • child bipolar disorder
  • adolescent bipolar disorder
  • pediatric bipolar disorder
  • fMRI
  • MRI
  • EEG
  • neurocognitive tasks
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In context

Bipolar Disorder

1,601 studies on the registry are indexed under Bipolar Disorder; 254 are open to participants now.

This study's enrollment of 50 is below the median of 160 across 329 observational studies indexed under Bipolar Disorder.

Browse Bipolar Disorder studies →

Lead sponsor

University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.

Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
7 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Bipolar Disorder

Inclusion criteria

  • Subject suffers clinically impairing symptoms of mood lability.
  • Child has resided with primary caretaker for at least 6 months.
  • Caretaker speaks sufficient English to complete all study evaluations and measures.

Exclusion criteria

Exclusion Criteria:

  • Lifetime history of mental retardation, autism, or primary diagnosis of psychosis.
  • Subject is pregnant or nursing.
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Study design

Time perspective
Cross-sectional
Enrollment
50 participants (actual)
Patient registry
No
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Study locations

1 site
  • UCLA Semel Institute for Neuroscience and Human Behavior
    Los Angeles, California 90095, United States
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References and documents

Publications

  • Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986 Dec;51(6):1173-82. doi: 10.1037//0022-3514.51.6.1173. PubMed 3806354 ↗
  • Bearden CE, Hoffman KM, Cannon TD. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord. 2001 Jun;3(3):106-50; discussion 151-3. doi: 10.1034/j.1399-5618.2001.030302.x. PubMed 11465675 ↗
  • Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry. 2003 Jun;60(6):601-9. doi: 10.1001/archpsyc.60.6.601. PubMed 12796223 ↗
  • Carlson GA. Mania and ADHD: comorbidity or confusion. J Affect Disord. 1998 Nov;51(2):177-87. doi: 10.1016/s0165-0327(98)00179-7. PubMed 10743850 ↗
  • Carlson GA. Juvenile mania versus ADHD. J Am Acad Child Adolesc Psychiatry. 1999 Apr;38(4):353-4. doi: 10.1097/00004583-199904000-00001. No abstract available. PubMed 10199100 ↗
  • Casey BJ, Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Schubert AB, Vauss YC, Vaituzis AC, Dickstein DP, Sarfatti SE, Rapoport JL. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83. doi: 10.1097/00004583-199703000-00016. PubMed 9055518 ↗
  • Castellanos FX, Giedd JN, Eckburg P, Marsh WL, Vaituzis AC, Kaysen D, Hamburger SD, Rapoport JL. Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder. Am J Psychiatry. 1994 Dec;151(12):1791-6. doi: 10.1176/ajp.151.12.1791. PubMed 7977887 ↗
  • Faraone SV, Biederman J, Wozniak J, Mundy E, Mennin D, O'Donnell D. Is comorbidity with ADHD a marker for juvenile-onset mania? J Am Acad Child Adolesc Psychiatry. 1997 Aug;36(8):1046-55. doi: 10.1097/00004583-199708000-00012. PubMed 9256584 ↗
  • Geller B, Luby J. Child and adolescent bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1168-76. doi: 10.1097/00004583-199709000-00008. Erratum In: J Am Child Adolesc Psychiatry 1997 Nov;36(11):1642. PubMed 9291717 ↗
  • Geller B, Tillman R, Craney JL, Bolhofner K. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry. 2004 May;61(5):459-67. doi: 10.1001/archpsyc.61.5.459. PubMed 15123490 ↗
  • Geller B, Williams M, Zimerman B, Frazier J, Beringer L, Warner KL. Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. J Affect Disord. 1998 Nov;51(2):81-91. doi: 10.1016/s0165-0327(98)00175-x. PubMed 10743841 ↗
  • Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL, Frazier J, Beringer L, Nickelsburg MJ. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol. 2002 Spring;12(1):11-25. doi: 10.1089/10445460252943533. PubMed 12014591 ↗
  • Gruber SA, Rogowska J, Yurgelun-Todd DA. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord. 2004 Oct 15;82(2):191-201. doi: 10.1016/j.jad.2003.10.010. PubMed 15488247 ↗
  • Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8. doi: 10.1097/00004583-199707000-00021. PubMed 9204677 ↗
  • Kent L, Craddock N. Is there a relationship between attention deficit hyperactivity disorder and bipolar disorder? J Affect Disord. 2003 Feb;73(3):211-21. doi: 10.1016/s0165-0327(02)00092-7. PubMed 12547289 ↗
  • Kovatchev B, Cox D, Hill R, Reeve R, Robeva R, Loboschefski T. A psychophysiological marker of attention deficit/hyperactivity disorder (ADHD)--defining the EEG consistency index. Appl Psychophysiol Biofeedback. 2001 Jun;26(2):127-40. doi: 10.1023/a:1011339206875. PubMed 11480163 ↗
  • Mostofsky SH, Cooper KL, Kates WR, Denckla MB, Kaufmann WE. Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2002 Oct 15;52(8):785-94. doi: 10.1016/s0006-3223(02)01412-9. PubMed 12372650 ↗
  • National Institute of Mental Health research roundtable on prepubertal bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2001 Aug;40(8):871-8. doi: 10.1097/00004583-200108000-00007. PubMed 11501685 ↗
  • Quraishi S, Frangou S. Neuropsychology of bipolar disorder: a review. J Affect Disord. 2002 Dec;72(3):209-26. doi: 10.1016/s0165-0327(02)00091-5. PubMed 12450638 ↗
  • Pennington BF, Ozonoff S. Executive functions and developmental psychopathology. J Child Psychol Psychiatry. 1996 Jan;37(1):51-87. doi: 10.1111/j.1469-7610.1996.tb01380.x. PubMed 8655658 ↗
  • Sax KW, Strakowski SM, Zimmerman ME, DelBello MP, Keck PE Jr, Hawkins JM. Frontosubcortical neuroanatomy and the continuous performance test in mania. Am J Psychiatry. 1999 Jan;156(1):139-41. doi: 10.1176/ajp.156.1.139. PubMed 9892312 ↗
  • Walcott CM, Landau S. The relation between disinhibition and emotion regulation in boys with attention deficit hyperactivity disorder. J Clin Child Adolesc Psychol. 2004 Dec;33(4):772-82. doi: 10.1207/s15374424jccp3304_12. PubMed 15498744 ↗
  • Wilder-Willis KE, Sax KW, Rosenberg HL, Fleck DE, Shear PK, Strakowski SM. Persistent attentional dysfunction in remitted bipolar disorder. Bipolar Disord. 2001 Apr;3(2):58-62. doi: 10.1034/j.1399-5618.2001.030202.x. PubMed 11333063 ↗
  • Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, Mennin D. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry. 1995 Jul;34(7):867-76. doi: 10.1097/00004583-199507000-00010. PubMed 7649957 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 13, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00961935
Lead sponsor
University of California, Los Angeles
Collaborators
National Institute of Mental Health (NIMH), The State Family Fund
Responsible party
James McCracken (Chair, University of California, Los Angeles) — Principal investigator
First posted
Aug 19, 2009
Start date
Aug 2008
Primary completion
Aug 2011
Completion
Sep 2011
Last update
Jan 13, 2016

Study contacts

Patricia Walshaw, Ph.D.
principal investigator · University of California, Los Angeles

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.

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