An interventional study of high fat/high saturated fat diet and low fat/low saturated fat diet in Fatty Liver, sponsored by University of Washington. Completed at 2 sites in United States. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-03.
Sponsored by University of Washington · Not applicable, Interventional, and Basic science
This study is designed to determine if the amount of fat and saturated fat in the diet contributes to the development of a condition called fatty liver disease in the absence of changes in weight.
A condition called non-alcoholic steatohepatitis is characterized by fat accumulation in the liver and associated inflammation. This condition is strongly associated with obesity, insulin resistance and type 2 diabetes. Diets high in saturated fat result in fatty liver, insulin resistance and liver injury in animal models. Dietary composition may contribute not only to hepatic fat accumulation and insulin resistance but may also promote inflammation leading to chronic liver disease in humans. This study will test the hypothesis that a diet high in fat and saturated fat contributes to liver fat accumulation, insulin resistance and inflammation by comparing the effects of a four-week, weight stable high fat/high saturated fat diet (55% calories from fat/25% saturated fat) with a four-week, weight stable low fat/low saturated fat diet (20% fat/8% saturated fat) in overweight and obese subjects.
1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.
This study's enrollment of 16 is below the median of 60 across 1,003 interventional studies indexed under Fatty Liver.
Browse Fatty Liver studies →University of Washington is the lead sponsor of 1,397 studies on the registry; 225 are open to participants now.
Of its 154 completed or terminated interventional studies of FDA-regulated products, 132 (86%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
4 weeks 55% fat/25% saturated fat isocaloric diet
Also known as: Diet
4 weeks 20% fat/8% saturated fat isocaloric diet
Also known as: Diet
hepatic triglyceride content by MRS
Time frame: 4 weeks
insulin sensitivity
Time frame: 4 weeks
systemic and subcutaneous adipose tissue inflammation
Time frame: 4 weeks
oxidative stress markers
Time frame: 4 weeks
This study is completed, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.
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University of Washington