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CompletedNCT00918541Updated Dec 23, 2011

Natural History of Atherosclerosis

An observational study in Atherosclerosis, sponsored by University of Zurich. Completed at 3 sites in Switzerland. Per ClinicalTrials.gov, last updated 2011-12-23.

Sponsored by University of Zurich · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
30
Sex
All
01

Study summary

20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

02

Conditions studied

  • Atherosclerosis

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Keywords

  • atherosclerotic disease
  • progression
  • natural progression of atherosclerotic disease
  • natural history of atherosclerosis at the level of the carotid artery as evaluated by MRI
03

In context

Atherosclerosis

1,567 studies on the registry are indexed under Atherosclerosis; 265 are open to participants now.

This study's enrollment of 30 is below the median of 223 across 571 observational studies indexed under Atherosclerosis.

Browse Atherosclerosis studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients of the districthospital Bellinzona

Inclusion criteria

  • stable carotid artery disease not requiring revascularization
  • asymptomatic carotid artery stenosis \< 80% or symptomatic patients with stenosis \< 60 %
  • prophylactic therapy with aspirin (> 100mg/day, statin, blood pressure therapy if indicated (goal \< 130/80 mmHg))
  • informed consent

Exclusion criteria

Exclusion Criteria:

  • non atherosclerotic occlusive disease (Bürgers disease)
  • uncontrolled BP (DBP > 110 mmHg and/or SBP > 200 mmHg)
  • hemorrhagic disease or platelet count \< 100'000 mm\^3
  • Known active liver disease (elevations of GPT GOT or increased ammonia)
  • impaired renal function (crea > 180 mmol/l)
  • pregnancy
  • severe claustrophobic reactions
  • short - term life - threatening pathology
  • physically unable to participate in the study
  • compliance not guaranteed
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
30 participants (actual)

Groups and cohorts

  • A

    asymptomatic patients with mild to moderate carotid artery stenosis

06

What researchers measure

Primary outcomes

  1. Progression of atherosclerotic plaque

    Time frame: 12 months

07

Study locations

3 sites
  • Ospedale San Giovanni Bellinzona
    Bellinzona, Switzerland
  • Ospedale San Giovanni
    Bellinzona, Switzerland
  • Cardiovascular Center Cardiology University Hospital Zürich
    Zürich, Switzerland
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 23, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00918541
Lead sponsor
University of Zurich
Collaborators
Districthospital of Bellinzona
Responsible party
Sponsor
First posted
Jun 11, 2009
Start date
Jan 2007
Primary completion
Mar 2010
Completion
Mar 2010
Last update
Dec 23, 2011

Study contacts

Roberto Corti, MD
principal investigator · Cardiovascular Center Cardiology, University Hospital Zürich, Zürich Switzerland
Augusto Gallino, MD
principal investigator · Ospedale San Giovanni Bellinzona, Switzerland

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2011. You cannot join it, but the record below documents what was studied.

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