CClinicalTrials.gg
CompletedNCT00897494Updated Mar 9, 2016

Identification of Biomarkers for Early Detection of Pancreatic Cancer

An observational study in Pancreatic Cancer, sponsored by Barbara Ann Karmanos Cancer Institute. Completed at 1 site in United States. Open to participants aged 18 Years to 120 Years. Per ClinicalTrials.gov, last updated 2016-03-09.

Sponsored by Barbara Ann Karmanos Cancer Institute · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
75
Ages
18 Years to 120 Years
Sex
All
01

Study summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.

Read the detailed description

OBJECTIVES:

  • Identify specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer.
  • Analyze serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis.

OUTLINE: Blood from patients is collected prior to treatment. Plasma proteins are analyzed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and/or electrospray mass spectrometry (ESI/MS).

PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.

02

Conditions studied

  • Pancreatic Cancer

Keywords

  • stage I pancreatic cancer
  • stage II pancreatic cancer
  • stage III pancreatic cancer
  • stage IV pancreatic cancer
03

In context

Pancreatic Neoplasms

3,235 studies on the registry are indexed under Pancreatic Neoplasms; 899 are open to participants now.

This study's enrollment of 75 is below the median of 200 across 620 observational studies indexed under Pancreatic Neoplasms.

Browse Pancreatic Neoplasms studies →

Lead sponsor

Barbara Ann Karmanos Cancer Institute is the lead sponsor of 158 studies on the registry; 19 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 6 (86%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 120 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Venous blood collection samples from newly dianosed

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of pancreatic cancer

    • Newly diagnosed disease
  • Planning to undergo surgery or other treatment for pancreatic cancer at Karmanos Cancer Institute or its affiliates

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
75 participants (actual)
Biospecimen retention
Samples without dna

Interventions

  • Geneticprotein expression analysis

    Venous blood collection

  • Otherlaboratory biomarker analysis

    Venous blood collection

  • Othermass spectrometry

    Venous blood collection

  • Othersurface-enhanced laser desorption/ionization-time of flight mass spectrometry

    Venous blood collection

06

What researchers measure

Primary outcomes

  1. Identification of specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer

    Time frame: Upon collection when patient agrees to provide a one time venous blood collection

  2. Analysis of serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis

    Time frame: After separation from the plasma

07

Study locations

1 site
  • Barbara Ann Karmanos Cancer Institute
    Detroit, Michigan 48201-1379, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 9, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00897494
Lead sponsor
Barbara Ann Karmanos Cancer Institute
Collaborators
National Cancer Institute (NCI)
Responsible party
Sponsor
First posted
May 12, 2009
Start date
Feb 2005
Primary completion
Nov 2009
Completion
Apr 2011
Last update
Mar 9, 2016

Study contacts

Fazlul Sarkar, MD
principal investigator · Barbara Ann Karmanos Cancer Institute

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion