An observational study in Insulin Resistance, sponsored by John Thyfault. Completed at 1 site in United States. Open to male participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-09-24.
Sponsored by John Thyfault · Observational
The purpose is to determine whether regular endurance exercise and/or body weight influence the way our nervous and vascular systems respond during the metabolism of meals.
To begin to examine this question we recruited healthy endurance-trained (high fit, HF) and normally active (average fit, AF) subjects. It is well characterized that chronic endurance training results in enhanced peripheral insulin sensitivity. Therefore, our rationale was that inclusion of two healthy subject groups, with distinct differences in insulin sensitivity, would allow us to investigate how enhanced insulin sensitivity influences insulin-mediated changes in central sympathetic outflow. Direct measurements of central sympathetic outflow to skeletal muscle (i.e., MSNA) were recorded, and a mixed meal was used as a physiological method to evoke robust and sustained increases in MSNA, which have been primarily attributed to insulin. We hypothesized that HF subjects would have a greater MSNA response, for a given plasma insulin concentration, following consumption of a mixed meal (i.e., greater central insulin sensitivity).
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's enrollment of 20 is below the median of 80 across 339 observational studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →This is the only study on the registry with John Thyfault as lead sponsor.
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young, lean, healthy men
Exclusion Criteria:
Men with high fitness (above VO2max of 60)
Men with average fitness (below VO2max of 50)
insulin/glucose response to mixed meal ingestion
Time frame: This study is cross-sectional. Primary and secondary measures will be assessed at a single timepoint.
MSNA
Time frame: This is a cross-sectional study. Primary and seconardy measures will be assessed at a single visit lasting 4-6 hours.
Blood flow
Time frame: This is a cross-sectional study. Primary and seconardy measures will be assessed at a single visit lasting 4-6 hours.
This study is completed, as verified in Sep 2015. You cannot join it, but the record below documents what was studied.
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