An interventional study of active tDCS and sham tDCS in Schizophrenia and Auditory Hallucinations, sponsored by Hôpital le Vinatier. Completed at 2 sites in 2 countries. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2017-03-01.
Sponsored by Hôpital le Vinatier · Not applicable, Interventional, and Treatment
The purpose of this study is to determine whether trans Direct Current Stimulation (tDCS) is effective in the treatment of auditory hallucinations in schizophrenia.
The project will investigate the use of a novel technique, transcranial direct current stimulation (tDCS) in the treatment of patients with schizophrenia. tDCS permit the application of an extremely weak continuous electrical current to the brain through an anode and a cathode applied on the scalp. Anodal stimulation appears to increase brain activity whereas cathodal stimulation has the opposite effect.
Using anodal \& cathodal tDCS the investigators aimed to treat auditory hallucinations, a symptoms of schizophrenia. The investigators plan to apply tDCS such that it can simultaneously increased activity in the frontal brain areas and reduce activity over temporoparietal cortex, 2 areas involved in the physiopathology of the disease. Real active stimulation will be compare to a sham condition in 60 patients (30 in each group). 30 patients will be included in a French center (Hospital le Vinatier, sponsor of the study) and 30 in Tunisia (laboratory "vulnerability to psychosis" (Pr Gaha) à Monastir).
132 studies on the registry are indexed under Hallucinations; 36 are open to participants now.
This study's enrollment of 46 is close to the median of 50 across 112 interventional studies indexed under Hallucinations.
Browse Hallucinations studies →Hôpital le Vinatier is the lead sponsor of 106 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
tDCS active; - Intensity = 2 milliamps (mA) during 20 minutes. ramp up/ramp down 30sec anodal tDCS applied over the left DLPFC combined with cathodal tDCS applied over the left temporoparietal junction (TPJ). 10 sessions, 2 per day
Procedure: active tDCS
tDCS placebo same electrode montage than in the active group. 30 sec of active tDCS in the beginning of the stimulation sessions; ramp up/ramp down 30 sec
Procedure: sham tDCS
Intensity 2 mA during 20 minutes, 2 times per day
Also known as: tDCS, transDirect Current Stimulation, Anodal tDCS, Cathodal tDCS
sham condition as delivered by the stimulator
Also known as: tDCS placebo
Auditory hallucinations measured by Auditory Hallucination Rating Scale (Hoffman et al., 2003)
Time frame: before, after 1 week of treatment and 2 times follow up (1 & 3 months)
Neurochemical impact of treatment measured by 1H-MRS (proton Magnetic Resonance Spectroscopy), DTI (Diffusion Tensor Imaging) and resting MRI
Time frame: 3 times: before treatment, immediately after treatment and a last evaluation 1 month after
This study is completed, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Hôpital le Vinatier