An interventional study of Aerobic interval training in Diastolic Dysfunction, sponsored by Norwegian University of Science and Technology. Completed at 1 site in Norway. Open to participants aged 70 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-18.
Sponsored by Norwegian University of Science and Technology · Not applicable, Interventional, and Prevention
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.
Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.
To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.
Norwegian University of Science and Technology is the lead sponsor of 487 studies on the registry; 52 are open to participants now.
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Exclusion Criteria:
Other: Aerobic interval training
High intensity aerobic interval training consists of 10 minutes warm up at \~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.
Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'.
Time frame: 12 weeks
Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'.
Time frame: 12weeks
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Norwegian University of Science and Technology