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CompletedNCT00760448Updated Jan 27, 2017

Comparison of Insulin Detemir and NPH With Respect to Lowering the Blood Sugar and Symptoms Experienced by Type 1 Diabetics During Hypoglycaemia

A Phase 1 interventional study of insulin detemir and insulin NPH in Diabetes and Diabetes Mellitus, Type 1, sponsored by Novo Nordisk A/S. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-27.

Sponsored by Novo Nordisk A/S · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
25
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This trial is conducted in UK. The aim of this clinical trial is to investigate lowering the blood sugar and symptoms experienced during hypoglycaemia

02

Conditions studied

  • Diabetes
  • Diabetes Mellitus, Type 1
03

In context

Diabetes Mellitus

10,925 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.

This study's enrollment of 25 is below the median of 80 across 8,367 interventional studies indexed under Diabetes Mellitus.

Browse Diabetes Mellitus studies →

Lead sponsor

Novo Nordisk A/S is the lead sponsor of 1,370 studies on the registry; 102 are open to participants now.

Of its 198 completed or terminated interventional studies of FDA-regulated products, 94 (47%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Signed and dated informed consent obtained before any trial-related activities.
  • Type 1 diabetes
  • Treatment with insulin for minimum three months
  • Duration of diabetes for more than 12 months
  • Body Mass Index (BMI) less than 30 kg/m2
  • HbA1c equal to or greater than 10 % based on analysis from central laboratory

Exclusion criteria

Exclusion Criteria:

  • Participation in any other clinical trial involving other investigational products within the last three months
  • Current treatment with insulin in a daily dose above 100 U
  • Episode of symptomatic hypoglycaemia, or a capillary plasma glucose value of less than 3.5 mmol/L in the past two weeks
  • Hypoglycaemic unawareness or severe autonomic neuropathy
  • Current treatment with drugs known to interfere with glucose metabolism such as systemic corticosteroids, non-selective beta-blockers and MAO inhibitors
  • Current treatment with oral antidiabetic drugs
  • Impaired hepatic function measured as ALAT of more than two times the upper reference limit
  • Impaired renal function measured as creatinine of more than 150 micromol/L (1.7 mg/dL)
  • Cardiac problems defined as decompensated heart failure (NYHA class III and IV) at any time and/or angina pectoris and/or myocardial infarction within the last 12 months
  • Known or suspected allergy to trial product or related products
  • Mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation
  • Blood donation of more than 500 mL within the last three months
  • Any condition that the Investigator and/or the Sponsor feels would interfere with study participation or evaluation of results
  • Pregnancy or intention of becoming pregnant, breast-feeding or judged to be using inadequate contraceptive methods. Adequate contraceptive methods are sterilisation, intrauterine device (IUD), oral contraceptives or consistent use of barrier methods
  • Previous participation in this trial
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
25 participants (actual)

Interventions

  • Druginsulin detemir
  • Druginsulin NPH
06

What researchers measure

Primary outcomes

  1. Baseline-adjusted hypoglycaemic symptoms score at nadir plasma glucose concentration based on the Edinburgh Hypoglycaemia Scale: autonomic symptoms, neuroglycopenic symptoms and general malaise

    Time frame: From -40 min and until immediately before trial product administration

07

Study locations

1 site
  • Novo Nordisk Investigational Site
    Guildford, GU2 7XX, United Kingdom
08

References and documents

Publications

  • Smeeton F, Shoajee-Moradie F, Jackson N, Westergaard L, Endahl L, Haahr HL, Umpleby M, Russell-Jones D. No Difference in Cognitive Function, Symptons or Counter-regulatory Responses after Induced Hypoglycemia in Subjects with Type 1 Diabetes. ADA 2007 2007; 56 (Suppl. 1): A168 (634-P)
  • Smeeton F, Shojaee Moradie F, Jones RH, Westergaard L, Haahr H, Umpleby AM, Russell-Jones DL. Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes. Diabetologia. 2009 Nov;52(11):2317-23. doi: 10.1007/s00125-009-1487-4. Epub 2009 Aug 26. PubMed 19707744 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 27, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00760448
Lead sponsor
Novo Nordisk A/S
Responsible party
Sponsor
First posted
Sep 26, 2008
Start date
Apr 2004
Primary completion
Oct 2005
Completion
Oct 2005
Last update
Jan 27, 2017

Study contacts

Global Clinical Registry (GCR, 1452)
study director · Novo Nordisk A/S

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.

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