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TerminatedNCT00752271Updated Dec 18, 2009

AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy

An observational study in Osteoarthritis, sponsored by National Institute on Aging (NIA). Terminated at 1 site in United States. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-12-18.

Sponsored by National Institute on Aging (NIA) · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
32
Ages
40 Years and older
Sex
All
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Study summary

The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.

Read the detailed description

This study will test the hypothesis that knee trauma (as exemplified by the arthroscopy procedure) causes inflammation that alters muscle activation patterns locally and also disrupts the balance between parasympathetic-sympathetic reflexes. It is hypothesized that these factors contribute to development and progression of knee osteoarthritis.

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Conditions studied

  • Osteoarthritis

Keywords

  • Arthroscopic
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In context

Arthritis

3,554 studies on the registry are indexed under Arthritis; 317 are open to participants now.

This study's planned enrollment of 32 is below the median of 155 across 1,057 observational studies indexed under Arthritis.

Browse Arthritis studies →

Lead sponsor

National Institute on Aging (NIA) is the lead sponsor of 157 studies on the registry; 13 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Orthopedic and arthritis clinics in the Baltimore/Washington DC area

Inclusion criteria

  • Age 40 or older
  • Potential candidate for knee arthroscopy for medial
  • Meniscal tear confirmed on MRI
  • Prior meniscal resection at least 1 year prior with a persistent knee effusion
  • Body mass index between 25-35 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Knee injury in the 1 month before the initial study evaluation
  • Knee surgery within 1 year before the initial study evaluation
  • Pace-maker or defibrillator, 2nd or 3rd degree heart block, or other abnormal rhythms
  • Current diagnosis of diabetes mellitus, a fasting glucose>100mg/dl or >140 mg/dl 2 hour after a glucose challenge
  • Current diagnosis of an inflammatory condition (e.g. rheumatoid arthritis, gout, etc)
  • Untreated thyroid disease
  • Morbid obesity (body mass index >35)
  • Neuropathy or nerve damage
  • Stroke or transient-ischemic attacks (mini-stroke)
  • Recent diagnosis of congestive heart failure or heart attack
  • Use of prednisone or chemotherapy, steroid or other joint or ant-inflammatory agents in the past 3 months
  • Current use of medications that influence heart rate
  • Cognitive impairment that limits your ability to provide informed consent
  • Pregnancy
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
32 participants (estimated)

Groups and cohorts

  • 1

    24 adults with meniscal damage for which arthroscopy is clinically indicated

  • 2

    8 adults who have already undergone meniscal resection to serve as positive controls

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Study locations

1 site
  • NIA Clinical Research Unit
    Baltimore, Maryland 21225, United States
07

References and documents

Publications

  • Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. Regulation of protein function by glycosaminoglycans--as exemplified by chemokines. Annu Rev Biochem. 2005;74:385-410. doi: 10.1146/annurev.biochem.72.121801.161747. PubMed 15952892 ↗
  • Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol. 2005 Mar;17(2):195-200. doi: 10.1097/01.bor.0000151406.64393.00. PubMed 15711235 ↗
  • Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, Huston J, Tracey KJ, Al-Abed Y, Metz CN. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med. 2005 Apr 4;201(7):1113-23. doi: 10.1084/jem.20040463. PubMed 15809354 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00752271
Lead sponsor
National Institute on Aging (NIA)
First posted
Sep 15, 2008
Start date
May 2008
Primary completion
May 2010 (estimated)
Completion
May 2010 (estimated)
Last update
Dec 18, 2009

Study contacts

Shari M. Ling, MD
principal investigator · National Institute on Aging (NIA)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Dec 2009. You cannot join it, but the record below documents what was studied.

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