An interventional study of laboratory biomarker analysis and screening questionnaire administration in Lung Cancer and Tobacco Use Disorder, sponsored by British Columbia Cancer Agency. Status unknown at 6 sites in Canada. Open to participants aged 50 Years to 75 Years. Per ClinicalTrials.gov, last updated 2012-03-09.
Sponsored by British Columbia Cancer Agency · Not applicable, Interventional, and Screening
RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to treat.
PURPOSE: This clinical trial is studying screening methods to see how well they find lung cancer early in current or former smokers.
OBJECTIVES:
OUTLINE: This is a multicenter study.
Participants undergo spirometry at baseline. Participants also undergo spiral CT scan at baseline and then at 1 and 2 years. Participants with semi-solid or solid nodules of 5-10 mm or ground glass opacity (GGO) 8-10 mm or those with growth of an existing nodule, development of a solid component in GGO, or a new nodule undergo an additional CT scan at 3 months. Some participants also undergo autofluorescence and white light bronchoscopy and bronchial biopsies.
Blood samples are collected at baseline and then annually for 2 years for biomarker studies. Participants diagnosed with lung cancer undergo additional blood sample collection for biomarker studies.
Participants complete questionnaires on sociodemographic factors, smoking, occupational exposure, family history, medical data, quality of life, and anxiety at baseline and then every 6 months for up to 2 years.
7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.
This study's enrollment of 2,504 is above the median of 60 across 5,295 interventional studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →British Columbia Cancer Agency is the lead sponsor of 149 studies on the registry; 32 are open to participants now.
Counted across the registry records on this site, refreshed daily.
DISEASE CHARACTERISTICS:
Current or former smoker
PATIENT CHARACTERISTICS:
No diagnosis of cancer, except for any of the following that were previously treated ≥ 5 years ago:
PRIOR CONCURRENT THERAPY:
Number of lung cancer cases detected early by spiral CT scan and autofluorescence bronchoscopy
Time frame: 24 months
Number of interval lung cancer cases
Time frame: 60 months
Stage distribution of lung cancer cases
Time frame: 60 months
Prevalence of lung nodules and differences in geographic distribution across Canada
Time frame: 60 months
Rate of detection of other incidental significant treatable diseases
Time frame: 60 months
Type and costs of downstream investigation and treatment related to abnormalities found by the screening procedures, whether the final diagnosis is lung cancer or not
Time frame: 60 months
Potential physical and psychosocial impact on participants
Time frame: 60 months
This study is status unknown, as verified in Mar 2012. You cannot join it, but the record below documents what was studied.
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British Columbia Cancer Agency