An observational study in Community Based Study, Cardiovascular Disease and Sudden Death, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Active, not recruiting at 1 site in France. Open to participants aged 50 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-11.
Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Observational
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.
5,368 studies on the registry are indexed under Cardiovascular Diseases; 939 are open to participants now.
This study's enrollment of 10,157 is above the median of 506 across 1,572 observational studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →Institut National de la Santé Et de la Recherche Médicale, France is the lead sponsor of 378 studies on the registry; 81 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult men and women affiliated to the public French Health Insurance System who benefited from a free general health check up paid by the French Health Insurance System
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Exclusion Criteria:
Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France
Other: Spider flash ECG, high-precision carotid echo-tracking, step test
cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes
cardiovascular disease (CVD)
incident coronary heart disease (CHD), stroke, sudden death, mortality
Time frame: through study completion, an average of 24 years
heart rate parameters and baroreflex sensitivity
as measured on the Spider Flash ECG and the carotid echotracking
Time frame: 4 Years
other CVD outcomes
heart failure, arterial aneurysms, venous thromboembolism (VTE), pulmonary embolism, arrhythmic events (atrial fibrillation, flutter)
Time frame: through study completion, an average of 24 years
This study is active, not recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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