ClinicalTrials.gg
Sign In
CompletedNCT00739856Updated Aug 22, 2008

Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder

An interventional study of Electroconvulsive Therapy in Posttraumatic Stress Disorder, sponsored by Government Medical College Srinagar. Completed at 1 site in India. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2008-08-22.

Sponsored by Government Medical College Srinagar · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Non-randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.

02

Conditions studied

  • Posttraumatic Stress Disorder

Keywords

  • posttraumatic stress disorder
  • electroconvulsive therapy
  • medication refractoriness
03

In context

Stress Disorders, Post-Traumatic

2,284 studies on the registry are indexed under Stress Disorders, Post-Traumatic; 557 are open to participants now.

This study's enrollment of 20 is below the median of 70 across 1,897 interventional studies indexed under Stress Disorders, Post-Traumatic.

Browse Stress Disorders, Post-Traumatic studies →

Lead sponsor

This is the only study on the registry with Government Medical College Srinagar as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Diagnosis of PTSD
  • Treatment resistance to 4 different antidepressants from 3 different classes
  • Treatment resistance to CBT
  • Severe PTSD

Exclusion criteria

Exclusion Criteria:

  • Significant substance abuse
  • Pregnancy
  • History of Traumatic Brain Injury
  • Unstable comorbid medical illness
  • Organic brain syndrome
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (actual)

Interventions

  • ProcedureElectroconvulsive Therapy

    ECT was administered using the MECTA-SR1 apparatus. The current amplitude was 800 mA, pulse width was 1.5 ms, and pulse frequency was 50 Hz. Stimulus duration was increased as required to elicit an adequate seizure, defined as at least 25 s with EEG monitoring. The ECT course was fixed, and comprised 6 treatments administered with bitemporal electrode placement at a twice-weekly frequency

06

What researchers measure

Primary outcomes

  1. Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS) SCORE

Secondary outcomes

  1. Montgomery-Asberg Depression Rating Scale score

    Time frame: baseline, 48 hrs post 3rd, 6th ECT

07

Study locations

1 site
  • Government Hospital for Psychiatric Disease
    Srinagar, Jammu and Kashmir 190003, India
08

References and documents

Publications

  • Margoob MA, Ali Z, Andrade C. Efficacy of ECT in chronic, severe, antidepressant- and CBT-refractory PTSD: an open, prospective study. Brain Stimul. 2010 Jan;3(1):28-35. doi: 10.1016/j.brs.2009.04.005. Epub 2009 May 27. PubMed 20633428 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jan 2005 and a primary completion of Dec 2005. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 20, 2008
First posted
Aug 22, 2008
Start
Jan 2005
Primary completionActual
Dec 2005
Last update
Aug 22, 2008
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 22, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00739856
Lead sponsor
Government Medical College Srinagar
Collaborators
Government Psychiatric Diseases Hospital, Srinagar
First posted
Aug 22, 2008
Start date
Jan 2005
Primary completion
Dec 2005
Last update
Aug 22, 2008

Study contacts

Mushtaq Margoob, MD
principal investigator · Government Medical College Srinagar

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2008. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Stress Disorders, Post-Traumatic →

Start the discussion