CClinicalTrials.gg
Status unknownNCT00716235Updated Jan 16, 2009

Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities

An observational study in Attention Deficit Hyperactivity Disorder, Autistic Disorder and Developmental Coordination Disorder, sponsored by Sheba Medical Center. Status unknown at 1 site in Israel. Open to participants aged 4 Years to 10 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-01-16.

Sponsored by Sheba Medical Center · Observational

The sponsor has not verified this record recently (last verified Jan 2009), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
160
Ages
4 Years to 10 Years
Sex
All
01

Study summary

The purpose of this study is to characterize the profile of executive functions and eye movements in several populations of children with developmental disabilities.

Read the detailed description

Abnormal Executive function (EF) profile was considered a major characteristic of Attention deficit / hyperactivity disorder (ADHD) and autism, and is frequently implicated in Developmental coordination disorder (DCD) children as well. The scientific literature implies that the EF profile among these three groups share some common abnormalities, but differ significantly in specific features. Abnormal EF profile may be a core feature of the developmental trajectory of each syndrome.

The fine measurement of eye movements may shed light on the underlying mechanisms of specific disorders, and point to abnormal attention, information processing, or motor organization. Gaze is an important component of social interaction. Eye contact and recognition of other's gaze direction are crucial to empathy assessment.

The current study will embark in the assessment of a wide range of EF in these populations and in a matched control group, as well as their relation to other important parameters such as daily function skills and comorbid neurobehavioral characteristics. It will also assess the pattern of eye movements in response to various visual stimuli in these populations. The main purpose is to characterize the similarities and differences of each of these populations, in terms of EF and eye movements.

Assessment methods:

Clinical parameters:

  • Intelligence tests (according to the child's age)
  • Communication: DSM-IV, ADOS, Stony Brook questionnaire
  • Motor / Coordination: Movement Advanced Battery for Children (M-ABC)
  • Attention: Conners Rating Scales - Revised (CRS-R 3rd ed.)
  • Sleep: Sleep habits questionnaire

Executive functions will be assessed using the following methods:

  • NEPSI-II
  • BRIEF questionnaire
  • Wisconsin Card Sorting Test
  • Tower of Hanoi

Eye movements will be measured using an infra-red video camera produced by ISCAN inc. the following visual stimuli will be presented:

  • Human faces presenting various emotions
  • Various objects
  • Saccade and anti-saccade tasks
02

Conditions studied

  • Attention Deficit Hyperactivity Disorder
  • Autistic Disorder
  • Developmental Coordination Disorder

Keywords

  • ADHD
  • ASD
  • PDD
  • DCD
  • Executive Functions
03

In context

Attention Deficit Disorder with Hyperactivity

1,514 studies on the registry are indexed under Attention Deficit Disorder with Hyperactivity; 255 are open to participants now.

This study's planned enrollment of 160 is above the median of 127 across 267 observational studies indexed under Attention Deficit Disorder with Hyperactivity.

Browse Attention Deficit Disorder with Hyperactivity studies →

Lead sponsor

Sheba Medical Center is the lead sponsor of 660 studies on the registry; 63 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
4 Years to 10 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Primary care clinic

Eligibility criteria

Inclusion Criteria:

  • Age of 4-10 years
  • A medical diagnosis according to the relevant study group
  • Normal vision without glasses or contact lens.

Exclusion Criteria - clinical groups:

  • Intelligence Quotient below 70
  • A known brain damage
  • A known hearing impairment
  • Regular use of medications (except for psychostimulants)
  • Evidence for a known genetic syndrome
  • History of fetal CMV infection, birth asphyxia, major head injury or epilepsy

Exclusion Criteria - control group:

  • Intelligence Quotient below 70
  • Regular use of medications
  • Evidence for a neurological / psychiatric disorder, birth injury, developmental delay, head injury, or other medical disorders that affect the central nervous system
  • Family History - first degree) of autism, DCD, ADHD or other neurological/psychiatric disorder
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
160 participants (estimated)

Groups and cohorts

  • DCD

    Children with a diagnosis of DCD

  • Autism

    Children with a diagnosis of Autism disorder

  • ADHD

    Children with a diagnosis of ADHD

  • Control

    Control group - children with no neurological or psychiatric problems

06

Study locations

1 of 1 sites recruiting
  • Weinberg Child Development Center, Sheba Medical Center, Tel-Hashomer
    Ramat-Gan, 52621, Israel
    Recruiting
07

References and documents

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 16, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00716235
Lead sponsor
Sheba Medical Center
Collaborators
Bar-Ilan University, Israel
First posted
Jul 16, 2008
Start date
Jan 2009
Primary completion
Dec 2009 (estimated)
Completion
Dec 2009 (estimated)
Last update
Jan 16, 2009

Study contacts

Lidia Gabis, MD
Contact
lidia.gabis@sheba.health.gov.il
+972-3-5302236
Raanan Raz, Ph.D
Contact
Raanan.Raz@sheba.health.gov.il
+972-3-5302236
Lidia Gabis, MD
principal investigator · Sheba Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2009. You cannot join it, but the record below documents what was studied.

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