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RecruitingNCT00695214Updated Jul 1, 2026

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

A Phase 2 interventional study of Propofol sedation in Sleep Apnea, Obstructive, sponsored by University of California, Los Angeles. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-01.

Sponsored by University of California, Los Angeles · Phase 2, Interventional, and Treatment

From the registry’s dates

  • Registered 4 years 4 months after the study started (first participant enrolled Feb 2004, registered Jun 2008).
  • Started Feb 2004; still recruiting 22 years 8 months later.
Phase
Phase 2
Study type
Interventional
Enrollment
800
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating moderate-substantial interrater and test-retest reliability. This research has also compared DISE findings to those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not responded to previous sleep apnea surgery. These papers have been published and available through PubMed. Additional research is ongoing, with examination of DISE findings, comparison to other evaluation techniques, and the association between DISE findings and surgical outcomes.

02

Conditions studied

  • Sleep Apnea, Obstructive

Keywords

  • Obstructive Sleep Apnea
  • Propofol
  • Sleep Endoscopy
03

In context

Sleep Apnea, Obstructive

2,198 studies on the registry are indexed under Sleep Apnea, Obstructive; 469 are open to participants now.

This study's planned enrollment of 800 is above the median of 53 across 1,448 interventional studies indexed under Sleep Apnea, Obstructive.

Browse Sleep Apnea, Obstructive studies →

Lead sponsor

University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.

Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Adult patients with OSA considering surgical treatment

Exclusion criteria

Exclusion Criteria:

  • Minors
  • Pregnant women
  • Patients unable to provide informed consent in English themselves
  • Prisoners
  • Allergy to propofol, soybean oil, egg lecithin or glycerol
  • Other contraindication to use of propofol (decision of anesthesiologist or otolaryngologist.)
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
800 participants (estimated)

Study arms

  • Other
    1

    OSA Patients considering surgical treatment

    Drug: Propofol sedation

Interventions

  • DrugPropofol sedation

    Patients receive an intravenous propofol infusion titrated to reach a target level of sedation, sleep with arousability to verbal stimuli.

06

What researchers measure

Primary outcomes

  1. Association between DISE and physical examination; between DISE and polysomnogram results; between DISE and awake Mueller maneuver; between DISE and lateral cephalometry; and between DISE findings and surgical outcomes

    Time frame: Preoperative and postoperative

07

Study locations

1 of 1 sites recruiting
  • UCLA Santa Monica Medical Center
    Santa Monica, California 90401, United States
    • Eric Kezirian, MD, MPH · Contact
    • Eric Kezirian, MD, MPH · Principal investigator
    Recruiting
08

References and documents

Publications

  • Kezirian EJ, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg AN. Interrater reliability of drug-induced sleep endoscopy. Arch Otolaryngol Head Neck Surg. 2010 Apr;136(4):393-7. doi: 10.1001/archoto.2010.26. PubMed 20403857 ↗
  • Rodriguez-Bruno K, Goldberg AN, McCulloch CE, Kezirian EJ. Test-retest reliability of drug-induced sleep endoscopy. Otolaryngol Head Neck Surg. 2009 May;140(5):646-51. doi: 10.1016/j.otohns.2009.01.012. PubMed 19393404 ↗
  • Kezirian EJ. Nonresponders to pharyngeal surgery for obstructive sleep apnea: insights from drug-induced sleep endoscopy. Laryngoscope. 2011 Jun;121(6):1320-6. doi: 10.1002/lary.21749. Epub 2011 May 6. PubMed 21557231 ↗
  • Kezirian EJ, Hohenhorst W, de Vries N. Drug-induced sleep endoscopy: the VOTE classification. Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1233-1236. doi: 10.1007/s00405-011-1633-8. Epub 2011 May 26. PubMed 21614467 ↗
  • George JR, Chung S, Nielsen I, Goldberg AN, Miller A, Kezirian EJ. Comparison of drug-induced sleep endoscopy and lateral cephalometry in obstructive sleep apnea. Laryngoscope. 2012 Nov;122(11):2600-5. doi: 10.1002/lary.23561. Epub 2012 Oct 19. PubMed 23086863 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 1, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00695214
Lead sponsor
University of California, Los Angeles
Collaborators
National Institutes of Health (NIH), American Academy of Otolaryngology-Head and Neck Surgery Foundation
Responsible party
Eric J. Kezirian, MD, MPH (Professor, Head and Neck Surgery, University of California, Los Angeles) — Principal investigator
First posted
Jun 11, 2008
Start date
Feb 2004
Primary completion
Jun 2035 (estimated)
Completion
Jun 2035 (estimated)
Last update
Jul 1, 2026

Study contacts

Eric J Kezirian, MD, MPH
Contact
ekezirian@mednet.ucla.edu
4242596559
Eric J Kezirian, MD, MPH
principal investigator · University of California, Los Angeles

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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