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CompletedNCT00642447Updated Mar 25, 2008

Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

A Phase 2/3 interventional study of helium:oxygen mixture in Bronchiolitis and Chronic Bronchitis, sponsored by Baqiyatallah Medical Sciences University. Completed at 1 site in Iran, Islamic Republic of. Open to male participants aged 38 Years to 59 Years. Per ClinicalTrials.gov, last updated 2008-03-25.

Sponsored by Baqiyatallah Medical Sciences University · Phase 2/3, Interventional, and Supportive care

Phase
Phase 2/3
Study type
Interventional
Enrollment
23
Allocation
Randomized
Ages
38 Years to 59 Years
Sex
Male
01

Study summary

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

02

Conditions studied

  • Bronchiolitis
  • Chronic Bronchitis

Keywords

  • noninvasive ventilation
  • helium
  • oxygen
  • sulfur mustard
  • chronic bronchitis
  • bronchiolitis
03

In context

Bronchiolitis

360 studies on the registry are indexed under Bronchiolitis; 43 are open to participants now.

This study's enrollment of 23 is below the median of 80 across 249 interventional studies indexed under Bronchiolitis.

Browse Bronchiolitis studies →

Lead sponsor

Baqiyatallah Medical Sciences University is the lead sponsor of 31 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
38 Years to 59 Years
Sexes eligible
Male
Accepts healthy volunteers
No

Inclusion criteria

  • exposure to sulfur mustard
  • worsening dyspnea during the last 10 days
  • respiratory rate of >25/min
  • arterial pH\<7.35
  • PaCO2 of >50 mmHg
  • PaO2 of \<50 mmHg

Exclusion criteria

Exclusion Criteria:

  • recent pneumothorax (\<1 month)
  • severe respiratory failure or hemodynamic instability with forthcoming intubation
  • FIO2 of \<0.4
  • impaired consciousness or absence of patient cooperation
  • facial lesions precluding NIPPV
05

Study design

Phase
Phase 2 / Phase 3
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
23 participants

Study arms

  • Experimental
    1

    Drug: helium:oxygen mixture

Interventions

  • Drughelium:oxygen mixture
06

Study locations

1 site
  • BMSU
    Tehran, 19945-546, Iran, Islamic Republic of
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 25, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00642447
Lead sponsor
Baqiyatallah Medical Sciences University
First posted
Mar 25, 2008
Start date
Apr 2007
Last update
Mar 25, 2008
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2008. You cannot join it, but the record below documents what was studied.

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