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CompletedNCT00632918DSCTUpdated Dec 29, 2008

Effects of Heart Rates and Variability of Heart Rates on Image Quality of Dual-Source CT Coronary Angiography

An observational study in CT and Coronary Angiography, sponsored by Far Eastern Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 21 Years to 78 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-12-29.

Sponsored by Far Eastern Memorial Hospital · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
149
Ages
21 Years to 78 Years
Sex
All
01

Study summary

The purpose of this study is to investigate the effects of heart rates (including maximum heart rate, average heart rate and minimum heart rate) and variability of heart rate on image quality of DSCT coronary angiography without control of heart rate experienced in our department.

Read the detailed description

The dual-source CT (DSCT) equipped with two X-ray tubes at 90 degree offset in the gantry can provide temporal resolution 83ms using mono-segmental reconstruction technique. The recent studies about the effect of heart rate on IQ of DSCT coronary angiography which concluded in adequate diagnostic IQ of dual-source CTCA without immediate pre-scanning heart rate control included chronic users of β-blocker focused on the influences of average heart rate, heart rate variability and coronary arterial calcifications on IQ. The effect of blooming artifact of calcification on IQ by far cannot be eliminated. Here, we investigate the effects of maximum heart rate, average heart rate, minimum heart rate and heart rate variability on the motion-related IQ of DSCT coronary angiography in patients without both pre-scanning heart rate control and chronic use of β-blocker agent, compared with that in chronic users of β-blocker agents.

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Conditions studied

  • CT
  • Coronary Angiography

Keywords

  • Image quality
  • Dual-source CT
  • Coronary angiography
  • Heart rate
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In context

Lead sponsor

Far Eastern Memorial Hospital is the lead sponsor of 253 studies on the registry; 38 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
21 Years to 78 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

The patients or examined persons from Taiwan.

Inclusion criteria

  • From Oct 2006 to Jan 2007, CT coronary angiographies of 180 consecutive adult patients, were performed in our hospital using a DSCT scanner. After exclusion of the patients according to the exclusion criteria, totally DSCT coronary angiographies of 133 adult patients (N=133) were enrolled in this study. Among those 133 patients, including 97 males and 36 females with a mean age of 53.9 (ranging from 21 to 78 year old), 50 patients were chronic β-blocker users (group 1) while the other 83 patients (group 2) were not chronic user of any medication controlling heart rate

Exclusion criteria

Exclusion Criteria:

  • The patients below 18 year old, patients with status post heterotopic heart transplantation (having two hearts in a chest), patients with status post coronary by-pass surgery and patients with post indwelling of coronary arterial stents
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Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
149 participants (actual)
Biospecimen retention
None retained
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What researchers measure

Primary outcomes

  1. Compare the effects of the heart rate variables on motion-related image qualities of DSCT coronary angiography between the group 1 patients of chronic beta-blocker users and the group 2 patients without medication of any heart-rate lowering agent.

    Time frame: About two months

Secondary outcomes

  1. Kappa Statistics, Descriptive Statistics, Chi-square test, Independent t-test, Pearson's correlation and linear regression method for statistic analysis.

    Time frame: About two to three months

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Study locations

1 site
  • Department of Medical Imaing, Far Eastern Memorial Hospital
    Pan-Chiao, Taipei 200, Taiwan
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References and documents

Publications

  • Leschka S, Scheffel H, Desbiolles L, Plass A, Gaemperli O, Valenta I, Husmann L, Flohr TG, Genoni M, Marincek B, Kaufmann PA, Alkadhi H. Image quality and reconstruction intervals of dual-source CT coronary angiography: recommendations for ECG-pulsing windowing. Invest Radiol. 2007 Aug;42(8):543-9. doi: 10.1097/RLI.0b013e31803b93cf. PubMed 17620936 ↗
  • Achenbach S, Ropers D, Kuettner A, Flohr T, Ohnesorge B, Bruder H, Theessen H, Karakaya M, Daniel WG, Bautz W, Kalender WA, Anders K. Contrast-enhanced coronary artery visualization by dual-source computed tomography--initial experience. Eur J Radiol. 2006 Mar;57(3):331-5. doi: 10.1016/j.ejrad.2005.12.017. Epub 2006 Jan 19. PubMed 16426789 ↗
  • Johnson TR, Nikolaou K, Wintersperger BJ, Leber AW, von Ziegler F, Rist C, Buhmann S, Knez A, Reiser MF, Becker CR. Dual-source CT cardiac imaging: initial experience. Eur Radiol. 2006 Jul;16(7):1409-15. doi: 10.1007/s00330-006-0298-y. Epub 2006 May 13. PubMed 16770652 ↗
  • Matt D, Scheffel H, Leschka S, Flohr TG, Marincek B, Kaufmann PA, Alkadhi H. Dual-source CT coronary angiography: image quality, mean heart rate, and heart rate variability. AJR Am J Roentgenol. 2007 Sep;189(3):567-73. doi: 10.2214/AJR.07.2078. PubMed 17715102 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 29, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00632918
Lead sponsor
Far Eastern Memorial Hospital
First posted
Mar 11, 2008
Start date
Oct 2007
Completion
Dec 2007
Last update
Dec 29, 2008

Study contacts

Wing-Keung Cheung, MD, CCD
principal investigator · Far Eastern Memorial Hospital
Kao-Lun Wang, MD
study chair · Far Eastern Memorial Hospital
Chen-I Yen, BSc
study chair · Far Eastern Memorial Hospital
Shu-Lin Tsen, BSc
study chair · Far Eastern Memorial Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2008. You cannot join it, but the record below documents what was studied.

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