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CompletedNCT00632892Updated Mar 11, 2008

The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

An observational study in Kidney Diseases, sponsored by Far Eastern Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2008-03-11.

Sponsored by Far Eastern Memorial Hospital · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
80
Ages
18 Years and older
Sex
All
01

Study summary

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

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Conditions studied

  • Kidney Diseases

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Keywords

  • oxidative stress markers in urine
  • urine norepinephrine
  • renal tubular enzyme markers
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In context

Kidney Diseases

3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.

This study's enrollment of 80 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.

Browse Kidney Diseases studies →

Lead sponsor

Far Eastern Memorial Hospital is the lead sponsor of 253 studies on the registry; 38 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent

Inclusion criteria

  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent

Exclusion criteria

Exclusion Criteria:

  1. Without signing informed consent
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
80 participants
Biospecimen retention
Samples without dna
06

Study locations

1 site
  • Far Eastern Memorial Hospital
    Pan Chiao, Taipei, 220, Taiwan
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 11, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00632892
Lead sponsor
Far Eastern Memorial Hospital
First posted
Mar 11, 2008
Start date
Dec 2007
Primary completion
Jan 2008
Last update
Mar 11, 2008

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2008. You cannot join it, but the record below documents what was studied.

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