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CompletedNCT00611312Updated Oct 3, 2012

Effects of Delivery Mode of Cognition Intervention in Early Alzheimer's Disease

A Phase 2 interventional study of Cognitive Training in Alzheimer's Disease, sponsored by University of Kansas. Completed at 1 site in United States. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2012-10-03.

Sponsored by University of Kansas · Phase 2, Interventional, and Supportive care

Phase
Phase 2
Study type
Interventional
Enrollment
25
Allocation
Non-randomized
Ages
60 Years and older
Sex
All
01

Study summary

The purpose of this study is to see if an intense two-week long cognitive training program helps the thinking ability of adults with very mild Alzheimer Disease. We anticipate that scores on clinical cognitive tests will be better after the training.

Read the detailed description

Twenty of the 30 subjects will be recruited to participate in functional magnetic resonance imaging (fMRI). Scanning will be done while subjects perform a verbal learning task. Ten subjects will be scanned before and after the two week training. Another ten will be scanned twice at a two week interval before beginning the cognitive training.

02

Conditions studied

  • Alzheimer's Disease

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Keywords

  • Alzheimer's disease
  • Cognitive training
03

In context

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.

This study's enrollment of 25 is below the median of 70 across 2,808 interventional studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

University of Kansas is the lead sponsor of 81 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of very mild Alzheimer's Disease (CDC of 0.5) and mild Alzheimer's Disease (CDC of 1.0)

Exclusion criteria

Exclusion Criteria:

  • Neurologic disorder other than Alzheimer's disease
05

Study design

Phase
Phase 2
Primary purpose
Supportive care
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
25 participants (actual)

Study arms

  • Experimental
    1

    Cognitive Training

    Behavioral: Cognitive Training

Interventions

  • BehavioralCognitive Training

    Intense cognitive training, two consecutive weeks, each weekday, 6 hours/day

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What researchers measure

Primary outcomes

  1. Composite score of 5 cognitive tests including 1)WAIS digit span, 2) word fluency, 3) trail making test-A 4) Rey Osterrieth complex figure and 5) MMSE

    Time frame: 2 weeks with FU at 2 and 4 months

Secondary outcomes

  1. Brain activity during functional brain imaging

    Time frame: 2 weeks

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Study locations

1 site
  • University of Kansas Medical Center
    Kansas City, Kansas 66160, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 3, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00611312
Lead sponsor
University of Kansas
Collaborators
Alzheimer's Association
Responsible party
Yvonne Colgrove, PT, PhD (Principal Investigator, University of Kansas) — Principal investigator
First posted
Feb 8, 2008
Start date
Feb 2008
Primary completion
May 2012
Completion
Sep 2012
Last update
Oct 3, 2012

Study contacts

Yvonne Colgrove, PhD, PT
principal investigator · University of Kansas Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.

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