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CompletedNCT00611156Updated Feb 8, 2008

Examination of the Effects of Four Different Spices on Energy Metabolism

An interventional study of ginger and black pepper in Healthy, sponsored by University of Copenhagen. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-02-08.

Sponsored by University of Copenhagen · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
22
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
Male
01

Study summary

The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.

Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.

Read the detailed description

Several pungent food ingredients, such as chili,and also other bioactive food ingredients, e.g. green tea, have been shown to be able to increase energy expenditure and fat oxidation during the hours following a meal containing the bioactive ingredient. Furthermore, we will also look at the subjects own feelings of appetite and thereby examine whether the appetite is affected by the spicy food. We expect to see some small effects on these parameters.

02

Conditions studied

  • Healthy

Keywords

  • Thermogenesis
  • Meal-induced thermogenesis
  • energy expenditure
  • fat oxidation
  • bioactive ingredients
  • spices
  • ginger
  • horseradish
  • black pepper
  • mustard
03

In context

Lead sponsor

University of Copenhagen is the lead sponsor of 465 studies on the registry; 63 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • male
  • healthy and not use medication (regularly)
  • normal weight
  • non smoker
  • tolerate and like spicy food
  • stable body weight last two months

Exclusion criteria

Exclusion Criteria:

  • increased blood pressure
  • abnormal EKG
  • mental, metabolic and chronic diseases
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Investigator)
Enrollment
22 participants (actual)

Study arms

  • Experimental
    A

    Spice

    Dietary Supplement: ginger

  • Experimental
    B

    Spice

    Dietary Supplement: black pepper

  • Experimental
    C

    Spice

    Dietary Supplement: horseradish

  • Experimental
    D

    Spice

    Dietary Supplement: mustard

  • Placebo comparator
    E

    Placebo

    Dietary Supplement: placebo

Interventions

  • Dietary supplementginger

    added to a brunch meal

  • Dietary supplementblack pepper

    Added to a brunch meal

  • Dietary supplementhorseradish

    Added to a brunch meal

  • Dietary supplementmustard

    Drug pages: Mechlorethamine · Mustard Gas

    Added to a brunch meal

  • Dietary supplementplacebo

    Added to a bruch meal

06

What researchers measure

Primary outcomes

  1. energy expenditure

    Time frame: November 2007

Secondary outcomes

  1. blood pressure

    Time frame: December 2007

  2. heart rate

    Time frame: December 2007

  3. VAS-scores for appetite, hunger, fullness, etc. - and palatability

    Time frame: November 2007

  4. tolerance

    Time frame: November 2007

  5. Fat and carbohydrate oxidation

    Time frame: November 2007

  6. Meal-induced thermogenesis

    Time frame: November 2007

07

Study locations

1 site
  • Department of Human Nutrition, The Royal Veterinary and Agricultural University
    Frederiksberg, DK-1958, Denmark
08

References and documents

Publications

  • Gregersen NT, Belza A, Jensen MG, Ritz C, Bitz C, Hels O, Frandsen E, Mela DJ, Astrup A. Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite, ad libitum energy intake and energy balance in human subjects. Br J Nutr. 2013 Feb 14;109(3):556-63. doi: 10.1017/S0007114512001201. Epub 2012 Jul 5. PubMed 23021155 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Oct 2006 and a completion of Jun 2007. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 28, 2008
First posted
Feb 8, 2008
Start
Oct 2006
CompletionActual
Jun 2007
Last update
Feb 8, 2008
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 8, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00611156
First posted
Feb 8, 2008
Start date
Oct 2006
Completion
Jun 2007
Last update
Feb 8, 2008

Study contacts

Arne Astrup, Professor MD
study chair · Department of Human Nutrition, RVAU

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2007. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drugs tested here: Ginger extract · Black pepper · Mechlorethamine · Mustard Gas

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