An interventional study of Remifentanil in Movement Disorders and Effect of Remifentanil, sponsored by Hadassah Medical Organization. Status unknown. Per ClinicalTrials.gov, last updated 2008-01-09.
Sponsored by Hadassah Medical Organization · Not applicable, Interventional, and Basic science
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.
320 studies on the registry are indexed under Movement Disorders; 98 are open to participants now.
This study's enrollment of 20 is below the median of 46 across 180 interventional studies indexed under Movement Disorders.
Browse Movement Disorders studies →Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.
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The patients get a period of sedation with remifentanil, before, during and after which, the changes in the electrical activity of the Basal Ganglia is recorded.
Drug: Remifentanil
After the mapping electrode is in situ, recording of baseline electrical activity is done for two-three minutes and an infusion of Remifentanil, 0.1 microgram per kilogram per minute is started. This procedure continues for a few minutes until the patient is sedated and then the infusion is stopped and the patient allowed to recover. The recordings continue during the whole procedure.
Electrical activity in the basal ganglia
Time frame: During the experiment
No study locations are listed for this record.
This study is status unknown, as verified in Dec 2007. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization