CClinicalTrials.gg
TerminatedNCT00585741Updated Feb 23, 2012

Pilot Study of 18F-FLT PET

An interventional study of Imaging with 18F-FLT PET and Imaging with 18F-FLT PET in CNS Brain Metastasis, Head and Neck Cancer and Lung Cancer, sponsored by University of Wisconsin, Madison. Terminated at 1 site in United States. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-02-23.

Sponsored by University of Wisconsin, Madison · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
15
Allocation
Non-randomized
Ages
18 Years and older
Sex
Female
01

Study summary

Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission

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Conditions studied

  • CNS Brain Metastasis
  • Head and Neck Cancer
  • Lung Cancer
  • Prostate Cancer
  • Esophageal Cancer

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03

In context

Brain Neoplasms

1,960 studies on the registry are indexed under Brain Neoplasms; 516 are open to participants now.

This study's enrollment of 15 is below the median of 40 across 1,458 interventional studies indexed under Brain Neoplasms.

Browse Brain Neoplasms studies →

Lead sponsor

University of Wisconsin, Madison is the lead sponsor of 1,161 studies on the registry; 182 are open to participants now.

Of its 151 completed or terminated interventional studies of FDA-regulated products, 114 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Able to tolerate a PET/CT scan
  • Age of 18 or older
  • signed informed consent
  • being considered for radiotherapy for treatment of CNS mets, Head and neck cancer, lung cancer, prostate cancer or esophageal cancer

Exclusion criteria

Exclusion Criteria:

  • Prior XRT to site being studied
  • severe claustrophobia or inability to tolerate PET/CT
  • unable to provide written consent
  • pregnant or breastfeeding women
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
15 participants (actual)

Study arms

  • Experimental
    2. Head and neck

    Imaging with 18F-FLT PET

    Procedure: Imaging with 18F-FLT PET

  • Experimental
    3. Lung

    Imaging with 18F-FLT PET

    Procedure: Imaging with 18F-FLT PET

  • Experimental
    4. prostate

    Imaging with 18F-FLT PET

    Procedure: Imaging with 18F-FLT PET

  • Experimental
    5. esophagus

    Imaging with 18F-FLT PET

    Procedure: Imaging with 18F-FLT PET

  • Experimental
    1.CNS

    Imaging with 18F-FLT PET

    Procedure: Imaging with 18F-FLT PET

Interventions

  • ProcedureImaging with 18F-FLT PET

    Imaging with 18F-FLT PET

  • ProcedureImaging with 18F-FLT PET

    Imaging with 18F-FLT PET

  • ProcedureImaging with 18F-FLT PET

    Imaging with 18F-FLT PET

  • ProcedureImaging with 18F-FLT PET

    Imaging with 18F-FLT PET

  • ProcedureImaging with 18F-FLT PET

    Imaging with 18F-FLT PET

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What researchers measure

Primary outcomes

  1. To test whether the cellular response to fractionated radiotherapy leads to observable global change in the uptake of 18F-FLT as assessed by PET imaging

    Time frame: end of study

Secondary outcomes

  1. To assess the technical and logistic feasibility of 18F-FLT scans in a population of cancer patients

    Time frame: end of study

07

Study locations

1 site
  • University of Wisconsin Hospital and clinis
    Madison, Wisconsin 53792, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 23, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00585741
Lead sponsor
University of Wisconsin, Madison
Responsible party
Sponsor
First posted
Jan 3, 2008
Start date
Dec 2006
Primary completion
Dec 2011
Completion
Dec 2011
Last update
Feb 23, 2012

Study contacts

Robert Jeraj, Ph.D.
principal investigator · University of Wisconsin, Madison

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Feb 2012. You cannot join it, but the record below documents what was studied.

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