Hematopoietic Stem Cell Transplant for Recurrent Non-Hodgkin's Lymphoma

• Pts with a diagnosis of indolent or aggressive B-cell non-Hodgkin's lymphoma who have failed > 3 prior therapies, or are chemo resistant or refractory. Patients must be otherwise eligible for high-dose therapy with the BEAM protocol and ABMT or PSCT.
• Pts without evidence of severe organ dysfunction.
• The pre-transplant bone marrow biopsy must show no evidence of marrow involvement if an autologous BMT is to be performed and adequate cellularity, alternatively autologous PSCT will be considered if the bone marrow involvement is \<25%.
• The pt must have no other major medical problems and specifically life expectancy must be at least 4 months post transplant, with a performance status Karnofsky score of >70.
• Pts with evidence that their tumor tissue expresses the CD20 antigen. Immunoperoxidase stains of tissue showing positive reactivity with L26 antibody or flow cytometry studies are acceptable evidence of CD20 positivity. Testing of tumor tissue from any time in the course of the patient's disease is acceptable.
• Pts must have normal renal function (creatinine \< 2.0 mg/dL) and hepatic function (bilirubin \< 2.0 mg/dL) within seven days of study entry.
• Pts with DLCO >50% of predicted.
• If pt is >60 years or has a significant cardiac history (MI or CHF) or has received >350 mg/m2 of Adriamycin and ejection fraction must be >40%.
• Pts must give written informed consent and sign an approved informed consent form prior to study entry.
• ts must have bidimensionally measurable disease.
• Females of child-bearing potential must have a negative serum pregnancy test prior to enrollment to the study, followed by the use of an effective method of birth control.

Exclusion Criteria:

• Pts with more than 25% of the intratrabecular marrow space involved by lymphoma in a unilateral bone marrow biopsy specimens as assessed microscopically prior to study entry.
• Pts who have received cytotoxic chemotherapy, radiation therapy or immunosuppressants within THREE weeks prior to the radioimmunoconjugate dose or who exhibit persistent clinical evidence of toxicity. The use of steroids must have been discontinued (except maintenance-dose steroids).
• Pts with obstructive hydronephrosis.
• Pts with evidence of active infection requiring intravenous antibiotics at the time of study entry.
• Pts with New York Heart Association class 3 or 4 heart disease or other serious illness that would preclude evaluation.
• Pts with prior malignancy other than lymphoma, except for adequately treated skin ca, in situ cervical ca, or other ca for which patient has been disease-free for 5 years.
• Pts with known HIV infection.
• Pts with known brain or leptomeningeal metastases.
• Pts who are pregnant. Patients of child-bearing potential must undergo a pregnancy test. Males and females must agree to use effective contraception during the study and females must continue effective contraception for one year following the radioimmunotherapy dose.
• Pts with previous allergic reactions to iodine. This does not include IV contrast materials.
• Pts who previously received radioimmunotherapy.
• Pts with progressive disease in a field that has been previously irradiated with more than 3500 cGy within the past year.
• Pts who are on another protocol involving non-FDA approved drugs or biologics.
• No vulnerable subjects will be entered into this study.
• Pts with a positive HAMA test at baseline will not be entered. Patients with a positive HAMA test at the end of the week following dosimetric dose administration may not continue on to receive the radioimmunotherapy dose without first contacting the FDA.
• Pts who have not harvested a minimum CD34+ count of 1.5 X 10 6/kg body weight or CFU-GM count of >2.5 X 10 4/kg may not continue onto receive the study treatment.
• Pts with prior HSCT following high-dose chemo or chemo/radiotherapy.