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WithdrawnNCT00567424Updated Apr 4, 2013

GW273225 Therapy Added To Current Seizure Treatments In Patients With Partial Seizures

A Phase 2 interventional study of GW273225 in Epilepsy, sponsored by GlaxoSmithKline. Withdrawn at 30 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-04-04.

Sponsored by GlaxoSmithKline · Phase 2, Interventional, and Treatment

Why this study was withdrawn
No longer viable
Phase
Phase 2
Study type
Interventional
Enrollment
0
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

Study to determine drug interactions between GW273225 and the anticonvulsants valproate, carbamazepine or phenytoin

02

Conditions studied

  • Epilepsy

Keywords

  • epilepsy
  • refractory
  • seizure
  • drug interactions
  • pharmacokinetics
03

In context

Epilepsy

1,805 studies on the registry are indexed under Epilepsy; 417 are open to participants now.

Browse Epilepsy studies →

Lead sponsor

GlaxoSmithKline is the lead sponsor of 3,562 studies on the registry; 117 are open to participants now.

Of its 258 completed or terminated interventional studies of FDA-regulated products, 232 (90%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Confident diagnosis of epilepsy
  • Currently on VPA, CBZ or PHT
  • >or= 4 seizures/4 weeks prior to screen

Exclusion criteria

Exclusion criteria:

  • Prior lamotrigine use (excluded if treatment discontinued for clinically significant safety reasons (i.e., rash, hypersensitivity)).
  • Females of childbearing potential on hormonal contraceptives or hormone replacement therapy.
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Interventions

  • DrugGW273225
06

What researchers measure

Primary outcomes

  1. Pharmacokinetic drug interactions with the most common inhibiting and inducing antiepileptic drugs AEDs: valproate(VPA), carbamazepine(CBZ) and phenytoin (PHT).

Secondary outcomes

  1. Safety/tolerability of GW273225 in adults with refractory epilepsy Efficacy of GW273225 in adults with refractory epilepsy Potential initial starting doses for a subsequent placebo-controlled dose-ranging Phase IIb study.

07

Study locations

30 sites
  • GSK Clinical Trials Call Center
    Phoenix, Arizona 85054, United States
  • GSK Clinical Trials Call Center
    Sun City, Arizona 85351, United States
  • GSK Clinical Trials Call Center
    Little Rock, Arkansas 72205, United States
  • GSK Clinical Trials Call Center
    San Jose, California 95128, United States
  • GSK Clinical Trials Call Center
    Santa Monica, California 90404, United States
  • GSK Clinical Trials Call Center
    Jacksonville, Florida 32209, United States
  • GSK Clinical Trials Call Center
    Tallahassee, Florida 32308, United States
  • GSK Clinical Trials Call Center
    Tampa, Florida 33613, United States
  • GSK Clinical Trials Call Center
    Chicago, Illinois 60612, United States
  • GSK Clinical Trials Call Center
    Springfield, Illinois 62704, United States
  • GSK Clinical Trials Call Center
    Iowa City, Iowa 52242, United States
  • GSK Clinical Trials Call Center
    Wichita, Kansas 67214, United States
  • GSK Clinical Trials Call Center
    Baltimore, Maryland 21287, United States
  • GSK Clinical Trials Call Center
    Boston, Massachusetts 02215, United States
  • GSK Clinical Trials Call Center
    Rochester, Minnesota 55905, United States
  • GSK Clinical Trials Call Center
    St. Cloud, Minnesota 56303, United States
  • GSK Clinical Trials Call Center
    Springfield, Missouri 65804, United States
  • GSK Clinical Trials Call Center
    St. Louis, Missouri 63310, United States
  • GSK Clinical Trials Call Center
    Amherst, New York 14226, United States
  • GSK Clinical Trials Call Center
    Durham, North Carolina 27560, United States
  • GSK Clinical Trials Call Center
    Cleveland, Ohio 44195, United States
  • GSK Clinical Trials Call Center
    Toledo, Ohio 43614, United States
  • GSK Clinical Trials Call Center
    Medford, Oregon 97504, United States
  • GSK Clinical Trials Call Center
    Portland, Oregon 97225, United States
  • GSK Clinical Trials Call Center
    Portland, Oregon 97239-3098, United States
  • GSK Clinical Trials Call Center
    Dallas, Texas 75230, United States
  • GSK Clinical Trials Call Center
    Burlington, Vermont 05401, United States
  • GSK Clinical Trials Call Center
    Richmond, Virginia 23219, United States
  • GSK Clinical Trials Call Center
    Roanoke, Virginia 24018, United States
  • GSK Clinical Trials Call Center
    Seattle, Washington 98104, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 4, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00567424
Lead sponsor
GlaxoSmithKline
First posted
Dec 5, 2007
Start date
Jul 2006
Primary completion
Mar 2008
Completion
Mar 2008
Last update
Apr 4, 2013

Study contacts

GSK Clinical Trials, MD
study director · GlaxoSmithKline
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.

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