An interventional study of Azithromycin and Placebo tablet in Bronchiolitis Obliterans and Bone Marrow Transplantation, sponsored by Hospital Authority, Hong Kong. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2011-06-16.
Sponsored by Hospital Authority, Hong Kong · Not applicable, Interventional, and Treatment
Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation (BMT). Although augmentation of immunosuppressive treatment might help but the only effective treatment for BOS is by lung transplantation.
Macrolide antibiotics, which have been licensed to use as antibacterial agents for decades, have been found to have immunomodulatory properties in addition to their antibacterial activity. Low dose Azithromycin, an antibiotic of the macrolide family, has been shown to have promising result in a pilot study in treating BOS associated with lung transplantation. We propose to perform a prospective, randomised, double blind study to test the efficacy of Azithromycin in treating BOS after BMT. Patients with proven BOS after BMT will be randomised into two groups based on lung function parameters. One group will receive low dose Azithromycin while placebo will be provided for the other group. Lung function will be serially monitored at 3 month, 6 months and 12 months after commencement of treatment with drug/placebo. If Azithromycin was proven effective in treating BOS then all patient with proven BOS should be treated with this drug.
89 studies on the registry are indexed under Bronchiolitis Obliterans; 11 are open to participants now.
This study's planned enrollment of 30 is close to the median of 30 across 61 interventional studies indexed under Bronchiolitis Obliterans.
Browse Bronchiolitis Obliterans studies →Hospital Authority, Hong Kong is the lead sponsor of 79 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Quality of life assessment by questionnaires
Time frame: 3 months after treatment
Spirometry
Time frame: 3 months after treatment
The record gives a start of Apr 2005 and a completion of Mar 2007. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Jun 2011. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Azithromycin
Hospital Authority, Hong Kong